RNASEL Study of Genetics of Prostate Cancer and its Relation to Clinical Staging

被引：0
作者：
Alvarez-Cubero, M. J. [1 ]
Saiz, M. [1 ]
Martinez-Gonzalez, L. J. [2 ]
Alvarez, J. C. [1 ,2 ]
Lorente, J. A. [1 ,2 ]
Cozar, J. M. [3 ]
机构：
[1] Univ Granada, Fac Med, Dept Med Legal & Toxicol, Lab Identificac Genet, Granada, Spain
[2] Univ Granada, Ctr Pfizer, GENYO, Granada, Spain
[3] Hosp Univ Virgen de las Nieves, Serv Urol, Granada, Spain
来源：
ACTAS UROLOGICAS ESPANOLAS | 2012年 / 36卷 / 05期
关键词：
Prostate cancer; Genetic; RNASEL; 2-5A-DEPENDENT RNASE; MUTATION; 471DELAAAG; HEREDITARY; RISK;
D O I：
10.1016/j.acuroe.2012.08.013
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Objectives: This study has aimed to find a possible genetic relationship between sporadic prostate cancers. An attempt is made to establish population subgroups in patients based on the genotype found and the aggressiveness of the cancer. Material and methods: A total of 231 patients with sporadic prostate cancer and 68 controls were selected. The subjects were selected by an urologist using clinical parameters such as PSA level and Gleason score. Both groups (patients and controls) were genotyped in RNASEL gene by sequencing the exons 1 and 3. Results: Statistically significant differences were found between controls and patients in some of the genotyped regions of the RNASEL gene (197L, D541E and R462Q). Conclusions: Thanks to the genetic profile in some regions of the genoma, such as the RNASEL gene, together with the combination of the clinical and environmental parameters, we can suggest a care and more personalized follow-up of each patient. (C) 2011 AEU. Published by Elsevier Espana, S.L. All rights reserved.
引用
收藏
页码：306 / 311
页数：6
相关论文
共 22 条
  • [1] Camp NJ, 2002, AM J HUM GENET, V147, P715
  • [2] RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases
    Casey, G
    Neville, PJ
    Plummer, SJ
    Xiang, Y
    Krumroy, LM
    Klein, EA
    Catalona, WJ
    Nupponen, N
    Carpten, JD
    Trent, JM
    Silverman, RH
    Witte, JS
    [J]. NATURE GENETICS, 2002, 32 (04) : 582 - 583
  • [3] The 471delAAAG mutation and C353T polymorphism in the RNASEL gene in sporadic and inherited cancer in Israel
    Dagan, Efrat
    Laitman, Yael
    Levanon, Nurit
    Feuer, Avner
    Sidi, Ami A.
    Baniel, Jack
    Korach, Yaacov
    Ben Baruch, Gilad
    Friedman, Eitan
    Gershoni-Baruch, Ruth
    [J]. FAMILIAL CANCER, 2006, 5 (04) : 389 - 395
  • [4] Granado de la Orden S, 2006, Actas Urol Esp, V30, P574
  • [5] Prostate cancer epidemiology
    Grönberg, H
    [J]. LANCET, 2003, 361 (9360) : 859 - 864
  • [6] A DOMINANT-NEGATIVE MUTANT OF 2-5A-DEPENDENT RNASE SUPPRESSES ANTIPROLIFERATIVE AND ANTIVIRAL EFFECTS OF INTERFERON
    HASSEL, BA
    ZHOU, A
    SOTOMAYOR, C
    MARAN, A
    SILVERMAN, RH
    [J]. EMBO JOURNAL, 1993, 12 (08) : 3297 - 3304
  • [7] Arg462Gln sequence variation in the prostate-cancer-susceptibility gene RNASEL and age of onset of hereditary non-polyposis colorectal cancer:: a case-control study
    Krüger, S
    Silber, AS
    Engel, C
    Görgens, H
    Mangold, E
    Pagenstecher, C
    Holinski-Feder, E
    Doeberitz, MV
    Moeslein, G
    Dietmaier, W
    Stemmler, S
    Friedl, W
    Rüschoff, J
    Schackert, HK
    [J]. LANCET ONCOLOGY, 2005, 6 (08) : 566 - 572
  • [8] Germline Mutation in RNASEL Predicts Increased Risk of Head and Neck, Uterine Cervix and Breast Cancer
    Madsen, Bo Eskerod
    Ramos, Eliana Marisa
    Boulard, Mathieu
    Duda, Katarzyna
    Overgaard, Jens
    Nordsmark, Marianne
    Wiuf, Carsten
    Hansen, Lise Lotte
    [J]. PLOS ONE, 2008, 3 (06):
  • [9] Mutation screening and association study of RNASEL as a prostate cancer susceptibility gene
    Maier, C
    Haeusler, J
    Herkommer, K
    Vesovic, Z
    Hoegel, J
    Vogel, W
    Paiss, T
    [J]. BRITISH JOURNAL OF CANCER, 2005, 92 (06) : 1159 - 1164
  • [10] Genetic variation in RNASEL associated with prostate cancer risk and progression
    Meyer, Mara S.
    Penney, Kathryn L.
    Stark, Jennifer R.
    Schumacher, Fredrick R.
    Sesso, Howard D.
    Loda, Massimo
    Fiorentino, Michelangelo
    Finn, Stephen
    Flavin, Richard J.
    Kurth, Tobias
    Price, Alkes L.
    Giovannucci, Edward L.
    Fall, Katja
    Stampfer, Meir J.
    Ma, Jing
    Mucci, Lorelei A.
    [J]. CARCINOGENESIS, 2010, 31 (09) : 1597 - 1603
123