Consequences of bile salt biotransformations by intestinal bacteria

被引:757
作者
Ridlon, Jason M. [1 ]
Harris, Spencer C. [2 ]
Bhowmik, Shiva [3 ]
Kang, Dae-Joong [2 ]
Hylemon, Phillip B. [2 ]
机构
[1] Univ Illinois, Dept Anim Sci, Urbana, IL USA
[2] Virginia Commonwealth Univ, Dept Microbiol & Immunol, Richmond, VA 23298 USA
[3] Scripps Res Inst, Dept Integrat Struct & Computat Biol, La Jolla, CA 92037 USA
关键词
bile acid 7 alpha-dehydroxylation; bile acid oxidoreductases; bile salt hydrolase; gut microbiota; secondary bile acids; CLOSTRIDIUM-DIFFICILE INFECTION; DNA STRAND BREAKS; URSODEOXYCHOLIC ACID; DEOXYCHOLIC-ACID; BIFIDOBACTERIUM-LONGUM; HYDROLASE ACTIVITY; COLORECTAL-CANCER; LIPID-COMPOSITION; CHOLIC-ACID; COLONIC CARCINOGENESIS;
D O I
10.1080/19490976.2015.1127483
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Emerging evidence strongly suggest that the human "microbiome" plays an important role in both health and disease. Bile acids function both as detergents molecules promoting nutrient absorption in the intestines and as hormones regulating nutrient metabolism. Bile acids regulate metabolism via activation of specific nuclear receptors (NR) and G-protein coupled receptors (GPCRs). The circulating bile acid pool composition consists of primary bile acids produced from cholesterol in the liver, and secondary bile acids formed by specific gut bacteria. The various biotransformation of bile acids carried out by gut bacteria appear to regulate the structure of the gut microbiome and host physiology. Increased levels of secondary bile acids are associated with specific diseases of the GI system. Elucidating methods to control the gut microbiome and bile acid pool composition in humans may lead to a reduction in some of the major diseases of the liver, gall bladder and colon.
引用
收藏
页码:22 / 39
页数:18
相关论文
共 126 条
  • [11] Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
    Buffie, Charlie G.
    Bucci, Vanni
    Stein, Richard R.
    McKenney, Peter T.
    Ling, Lilan
    Gobourne, Asia
    No, Daniel
    Liu, Hui
    Kinnebrew, Melissa
    Viale, Agnes
    Littmann, Eric
    van den Brink, Marcel R. M.
    Jenq, Robert R.
    Taur, Ying
    Sander, Chris
    Cross, Justin R.
    Toussaint, Nora C.
    Xavier, Joao B.
    Pamer, Eric G.
    [J]. NATURE, 2015, 517 (7533) : 205 - U207
  • [12] TRANSBILAYER MOVEMENT OF BILE-ACIDS IN MODEL MEMBRANES
    CABRAL, DJ
    SMALL, DM
    LILLY, HS
    HAMILTON, JA
    [J]. BIOCHEMISTRY, 1987, 26 (07) : 1801 - 1804
  • [13] Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism
    Campbell, Yan
    Fantacone, Mary L.
    Gombart, Adrian F.
    [J]. EUROPEAN JOURNAL OF NUTRITION, 2012, 51 (08) : 899 - 907
  • [14] Chemoprevention of colorectal cancer with ursodeoxycholic acid: Cons
    Carey, Elizabeth J.
    Lindor, Keith D.
    [J]. CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2012, 36 : S61 - S64
  • [15] MOLECULAR-CLONING OF BILE-ACID 7-DEHYDROXYLASE FROM EUBACTERIUM SP STRAIN VPI-12708
    COLEMAN, JP
    WHITE, WB
    HYLEMON, PB
    [J]. JOURNAL OF BACTERIOLOGY, 1987, 169 (04) : 1516 - 1521
  • [16] CLONING AND CHARACTERIZATION OF A CONJUGATED BILE-ACID HYRDROLASE GENE FROM CLOSTRIDIUM-PERFRINGENS
    COLEMAN, JP
    HUDSON, LL
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1995, 61 (07) : 2514 - 2520
  • [17] MEMBRANE LIPID-COMPOSITION AND SUSCEPTIBILITY TO BILE-SALT DAMAGE
    COLEMAN, R
    LOWE, PJ
    BILLINGTON, D
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1980, 599 (01) : 294 - 300
  • [18] Primary Biliary Cirrhosis Therapeutic Advances
    Czul, Frank
    Peyton, Adam
    Levy, Cynthia
    [J]. CLINICS IN LIVER DISEASE, 2013, 17 (02) : 229 - +
  • [19] Bile Salts Control the Antimicrobial Peptide Cathelicidin Through Nuclear Receptors in the Human Biliary Epithelium
    D'Aldebert, Emilie
    Mve, Marie-Jeanne Biyeyeme Bi
    Mergey, Martine
    Wendum, Dominique
    Firrincieli, Delphine
    Coilly, Audrey
    Fouassier, Laura
    Corpechot, Christophe
    Poupon, Raoul
    Housset, Chantal
    Chignard, Nicolas
    [J]. GASTROENTEROLOGY, 2009, 136 (04) : 1435 - 1443
  • [20] Diet rapidly and reproducibly alters the human gut microbiome
    David, Lawrence A.
    Maurice, Corinne F.
    Carmody, Rachel N.
    Gootenberg, David B.
    Button, Julie E.
    Wolfe, Benjamin E.
    Ling, Alisha V.
    Devlin, A. Sloan
    Varma, Yug
    Fischbach, Michael A.
    Biddinger, Sudha B.
    Dutton, Rachel J.
    Turnbaugh, Peter J.
    [J]. NATURE, 2014, 505 (7484) : 559 - +