Prognostic Impact of Serum Immunoglobulin Heavy/Light Chain Ratio in Patients with Multiple Myeloma in Complete Remission after Autologous Stem Cell Transplantation

被引：22
作者：
Tovar, Natalia
Fernandez de Larrea, Carlos
Elena, Montserrat [2 ]
Teresa Cibeira, M.
Arostegui, Juan I. [3 ]
Rosinol, Laura
Filella, Xavier [2 ]
Yaguee, Jordi [3 ]
Blade, Joan [1 ]
机构：
[1] Univ Barcelona, Dept Hematol, Serv Hematol, Hosp Clin Barcelona,Inst Invest Biomed August Pi, E-08036 Barcelona, Spain
[2] Univ Barcelona, Dept Biochem, Hosp Clin Barcelona, Inst Invest Biomed August Pi I Sunyer, E-08036 Barcelona, Spain
[3] Univ Barcelona, Dept Immunol, Amyloidosis & Myeloma Unit, Hosp Clin Barcelona,Inst Invest Biomed August Pi, E-08036 Barcelona, Spain
来源：
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2012年 / 18卷 / 07期
关键词：
Residual disease; Isotype; Immune recovery; Plasma cell dyscrasia; IMMUNOFIXATION; THERAPY; BANDS;
D O I：
10.1016/j.bbmt.2012.03.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Immunoglobulin heavy/light chain (HLC) ratios were studied in 37 patients with multiple myeloma in complete remission after autologous hematopoietic stem cell transplantation. Increased IgA kappa/IgA lambda and IgM kappa/IgM lambda ratios were associated with longer progression-free survival (P = .006 and .01, respectively). A statistical trend toward a longer overall survival was also observed for the IgA kappa/IgA lambda ratio (P = .068). Considering the original immunoglobulin isotype, our results indicate that an increased kappa/lambda ratio of the uninvolved isotype is associated with longer progression-free survival and overall survival. This is the first report demonstrating the association between the HLC ratio and sustained complete remission in patients with multiple myeloma. Our results suggest that the HLC ratio is a surrogate marker of immune recovery after myeloablative transplantation, rather than as a marker of minimal residual disease. Biol Blood Marrow Transplant 18: 1076-1079 (2012) (C) 2012 American Society for Blood and Marrow Transplantation
引用
收藏
页码：1076 / 1079
页数：4
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