Epithelial-mesenchymal transition (EMT) and metastasis: yes, no, maybe?

被引：402

作者：

Diepenbruck, Maren ^{[1
]}

Christofori, Gerhard ^{[1
]}

机构：

[1] Univ Basel, Dept Biomed, CH-4058 Basel, Switzerland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2016年 / 43卷

基金：

瑞士国家科学基金会;

关键词：

MIR-200; FAMILY; COLORECTAL-CANCER; TUMOR PROGRESSION; FEEDBACK LOOP; STEM-CELLS; DISSEMINATION; EXPRESSION; PLASTICITY; BETA; COLONIZATION;

D O I：

10.1016/j.ceb.2016.06.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

An epithelial to mesenchymal transition (EMT) is a process of cell remodeling critical during embryonic development and organogenesis. During an EMT, epithelial cells lose their polarized organization and acquire migratory and invasive capabilities. While a plethora of experimental results have indicated that manipulating an EMT also affects cancer metastasis, its reverse process, a mesenchymal to epithelial transition (MET), seems to support metastatic outgrowth in distant organs. Moreover, recent reports investigating cancer cells circulating in the blood stream or employing genetic lineage-tracing have questioned a critical role of an EMT in metastasis formation. Hence, we need to better understand the molecular networks underlying the cell plasticity conferred by an EMT or a MET and its functional contribution to malignant tumor progression.

引用

页码：7 / 13

页数：7

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