Circular RNAs and their roles in head and neck cancers

被引：51

作者：

Guo, Yang ^{[1
]}

Yang, Jiechao ^{[1
]}

Huang, Qiang ^{[1
]}

Hsueh, Chiyao ^{[1
]}

Zheng, Juan ^{[1
]}

Wu, Chunping ^{[1
]}

Chen, Hui ^{[1
]}

Zhou, Liang ^{[1
]}

机构：

[1] Fudan Univ, Eye & ENT Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shanghai Key Clin Disciplines Otorhinolaryngol, Shanghai, Peoples R China

来源：

MOLECULAR CANCER | 2019年 / 18卷 / 1期

基金：

中国国家自然科学基金;

关键词：

Circular RNA; Biogenesis; Characteristics; Head and neck cancer; Sponge function; Biomarker; SQUAMOUS-CELL CARCINOMA; NONCODING RNA; STEM-CELLS; MICRORNA EXPRESSION; BLADDER-CANCER; EBV DNA; IDENTIFICATION; BIOMARKER; TRANSLATION; EPIDEMIOLOGY;

D O I：

10.1186/s12943-019-1003-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Circular RNAs are abundant endogenous non-coding RNA with no 5 cap and 3 polyadenylation tail that modify liner mRNAs and have no terminal structures. Our knowledge of the biogenesis of circular RNAs has been expanded, and circular RNAs were shown to be key regulators of various diseases, especially cancers. Head and neck cancers are the sixth most popular cancers worldwide, and the overall survival rates remain unsatisfactory. Recent studies have indicated that circular RNAs are involved in the tumorigenesis, progression, invasion and chemosensitivity of head and neck cancers and that some circular RNAs could serve as diagnostic and prognostic biomarkers. In this study, we summarize research advances in the regulation of circular RNA biogenesis, their characteristics and functions, the involvement of circular RNAs in the pathophysiology of head and neck cancers and their potential clinical utilization, as well as the likely directions of future studies.

引用

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