Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

被引：56

作者：

Han, Sang Won ^{[1
]}

Lee, Sung-Soo ^{[2
]}

Kim, Seo Hyun ^{[2
]}

Lee, Jun Hong ^{[5
]}

Kim, Gyu Sik ^{[5
]}

Kim, Ok-Joon ^{[6
]}

Koh, Im-Seok ^{[3
]}

Lee, Jong Yun ^{[3
]}

Suk, Seung-Han ^{[7
]}

Lee, Sung Ik ^{[7
]}

Nam, Hyo Suk ^{[4
]}

Kim, Won-Joo ^{[4
]}

Yong, Seok Woo ^{[8
]}

Lee, Kyung-Yul ^{[4
]}

Park, Jae Hyeon ^{[1
]}

机构：

[1] Inje Univ, Coll Med, Sanggye Paik Hosp, Dept Neurol, Seoul, South Korea

[2] Yonsei Univ, Wonju Coll Med, Seoul 135720, South Korea

[3] Natl Med Ctr, Seoul, South Korea

[4] Yonsei Univ, Coll Med, Seoul 135720, South Korea

[5] Ilsan Hosp, Natl Hlth Insurance Corp, Koyang, South Korea

[6] CHA Univ, Coll Med, Pochon, South Korea

[7] Wonkwang Univ, Coll Med, Sanbon Hosp, Gunpo, South Korea

[8] Ajou Univ, Coll Med, Suwon 441749, South Korea

来源：

EUROPEAN NEUROLOGY | 2013年 / 69卷 / 01期

关键词：

Antiplatelet activity; Lacunar infarcts; Transcranial Doppler; Pulsatility index; Cilostazol; ISCHEMIC-STROKE; CEREBRAL AUTOREGULATION; ARTERIAL PULSATILITY; HYPOTHESIS; INHIBITOR; RATS;

D O I：

10.1159/000338247

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: This study is intended to evaluate the propensities of cilostazol to reduce the pulsatility index (PI) in patients with acute lacunar infarction using the serial transcranial Doppler (TCD) examinations. Methods: In a multicenter, randomized, double-blind, placebo-controlled trial, patients were randomly assigned to receive either placebo or 100 mg cilostazol twice a day as well as aspirin 100 mg a day. The primary outcomes were the changes of middle cerebral artery (MCA) and basilar artery (BA) PIs at 14 and 90 days from the baseline TCD study. This study is registered with ClinicalTrials.gov (NCT00741286). Results: Trial medication was given to 203 patients, with 100 receiving cilostazol and 103 receiving placebo, and 164 were included in the per-protocol analysis of the primary outcome. Results from the linear mixed model showed that significant effects were obtained for time-by-group interactions (p = 0.008 in right MCA, p = 0.015 in left MCA, p = 0.002 in BA), suggesting that changes of PIs from the baseline to the 90-day study were different across the groups. Conclusions: Cilostazol further decreased TCD PIs at 90 days from baseline compared to placebo in acute lacunar infarction. This result may be related to pleiotropic effects, such as vasodilation, beyond its antiplatelet activity. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：33 / 40

页数：8

共 31 条

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