A mitochondria-targeted red-emitting probe for imaging hydrogen sulfide in living cells and zebrafish

被引：25

作者：

Ismail, Ismail ^{[1
,2
]}

Wang, Dan ^{[1
,2
]}

Wang, Dawei ^{[1
,2
]}

Niu, Cuili ^{[1
,2
]}

Huang, Haojie ^{[3
,4
]}

Yi, Long ^{[3
,4
,5
]}

Xi, Zhen ^{[1
,2
,5
]}

机构：

[1] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

[2] Nankai Univ, Dept Biol Chem, Natl Engn Res Ctr Pesticide Tianjin, Coll Chem, Tianjin 300071, Peoples R China

[3] BUCT, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China

[4] BUCT, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China

[5] Collaborat Innovat Ctr Chem Sci & Engn Tianjin, Tianjin 300071, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 13期

基金：

国家重点研发计划;

关键词：

RATIOMETRIC FLUORESCENT-PROBE; SENSITIVE DETECTION; RAPID DETECTION; H2S SYNTHESIS; CANCER-CELLS; THIOLYSIS; REDUCTION; SPECTRA; DESIGN;

D O I：

10.1039/c8ob03219j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydrogen sulfide (H2S) is an important endogenous signaling molecule with multiple biological functions. Based on the thiolysis of NBD (7-nitro-1,2,3-benzoxadiazole) amine, herein we rationally design and synthesize a new fluorescent probe 1 for the detection of mitochondrial H2S in living cells. Probe 1 displays bright red-emitting fluorescence after H2S activation (., 0.77). 1 shows higher selectivity and sensitivity for H2S than the red-emitting probe Rho-NBD (ChemBioChem, 2016, 17, 962). Moreover, 1 is water-soluble, cell-membrane-permeable, of low cytotoxicity and mitochondria-targeting, and can be employed for monitoring mitochondrial H2S in living cells.

引用

页码：3389 / 3395

页数：7

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