With the growth of social economy, more and more high to the requirement of animal husbandry. With the brisk development of pig raising production, we have realized that how to improve the effectiveness of pig raising, disease warning and prevention is of great significance. In this research, by applying GM (1, 1) model of gray system theory, we try to forecast the pig disease based on the mortality rate of pig disease in a Jilin Provincial village. From the results, we can see the error between predicted values and measured values is very small and the fitting effect is excellent, which indicate that the method to predict pig disease is feasible, meanwhile, it will play a great role in health epidemic and disease prevention.