Sensitivity Analysis and Robust Experimental Design of a Signal Transduction Pathway System

被引：52

作者：

Yue, Hong ^{[1
,4
,5
]}

Brown, Martin ^{[2
]}

He, Fei ^{[2
]}

Jia, Jianfang ^{[3
]}

Kell, Douglas B. ^{[1
,4
,5
]}

机构：

[1] Univ Strathclyde, Dept Elect & Elect Engn, Glasgow G1 1QD, Lanark, Scotland

[2] Univ Manchester, Sch Elect & Elect Engn, Manchester M60 1QD, Lancs, England

[3] North Univ China, Dept Automat, Taiyuan 030051, Peoples R China

[4] Univ Manchester, Sch Chem, Manchester M1 7ND, Lancs, England

[5] Univ Manchester, Manchester Interdisciplinary Bioctr, Manchester M1 7ND, Lancs, England

来源：

INTERNATIONAL JOURNAL OF CHEMICAL KINETICS | 2008年 / 40卷 / 11期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1002/kin.20369

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Experimental design for cellular networks based on sensitivity analysis is studied in this work. Both optimal and robust experimental design strategies are developed for the I kappa B-NF-kappa B signal transduction model. Based on local sensitivity analysis, the initial IKK intensity is calculated using an optimal experimental design process, and several scalarization measures of the Fisher information matrix are compared Global sensitivity analysis and robust experimental design techniques are then developed to consider parametric uncertainties in the model, The modified Morris method is employed in global sensitivity analysis, and a semidefinite programming method is exploited to implement the robust experimental design for the problem of measurement set selection. The parametric impacts on the oscillatory behavior of NF-kappa B in the nucleus are also discussed. (c) 2008 Wiley Periodicals, Inc. Int J Chem Kinet 40: 730-741, 2008

引用

页码：730 / 741

页数：12

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