Structure and Function of the Non-Structural Protein of Dengue Virus and its Applications in Antiviral Therapy

被引：8
作者：
Xie, Qian [1 ]
Zhang, Bao [1 ]
Yu, JianHai [1 ]
Wu, Qinghua [1 ]
Yang, Fangji [2 ,3 ]
Cao, Hong [1 ]
Zhao, Wei [1 ]
机构：
[1] Southern Med Univ, Sch Publ Hlth, Lab Biosafety Level 3, Guangdong Prov Key Lab Trop Dis Res, Guangzhou 510515, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 3, Key Lab Liver Dis Guangdong Prov, Guangzhou, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 3, Dept Infect Dis, Guangzhou, Guangdong, Peoples R China
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2017年 / 17卷 / 03期
关键词：
Dengue virus; Non-structural protein; Structure; Function; Antiviral therapy; ENDOTHELIAL-CELL APOPTOSIS; NS3; PROTEIN; ANTIBODIES; INHIBITION; INSIGHTS; VACCINE;
D O I：
10.2174/1568026616666160829155327
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Dengue fever, a type of global and tropical infectious disease, and its prevention has become a challenging issue worldwide. Antibody-dependent enhancement effects and the virus pathogenic mechanism have not yet been fully elucidated, hindering the development of dengue fever prevention and suitable drug treatment. There is currently no specific prevention and therapy in clinical trials, however, in recent years, studies have focused on the pathogenesis and treatment of dengue. Research focusing on dengue virus nonstructural protein in special drugs for the prevention and control of dengue fever is a new progress leading to improved understanding regarding the prevention and control of dengue fever and suitable drugs for the treatment. The main challenges regarding the structure of dengue virus nonstructural protein and the drugs for antiviral therapy are summarized in this paper.
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收藏
页码：371 / 380
页数：10
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