Role of osteoprotegerin in vascular disorders of the end-stage renal disease patients

被引：8
|
作者：
Moldovan, Diana [1 ]
Kacso, Ina Maria [1 ]
Rusu, Crina [1 ]
Potra, Alina [1 ]
Bondor, Cosmina Ioana [2 ]
Moldovan, Ioan [3 ]
Patiu, Ioan Mihai [4 ]
Vladutiu, Dan [1 ]
Caprioara, Mirela Gherman [1 ]
机构：
[1] Univ Med & Pharm Iuliu Hatieganu, Dept Nephrol, Cluj Napoca, Romania
[2] Univ Med & Pharm Iuliu Hatieganu, Dept Stat, Cluj Napoca, Romania
[3] Emergency Mil Hosp, Cluj Napoca, Romania
[4] Nefromed Dialysis Ctr, Cluj Napoca, Romania
来源：
BIOMARKERS | 2015年 / 20卷 / 02期
关键词：
Cardiovascular disease; immunotoxicity; renal disease; CHRONIC KIDNEY-DISEASE; INTIMA-MEDIA THICKNESS; SERUM OSTEOPROTEGERIN; CARDIOVASCULAR EVENTS; FETUIN-A; ELEVATED OSTEOPROTEGERIN; CALCIFICATION INHIBITORS; PLASMA OSTEOPROTEGERIN; HEMODIALYSIS; ARTERY;
D O I：
10.3109/1354750X.2014.1000376
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To assess the osteoprotegerin (OPG) relationship with cardiovascular complications in hemodialysis (HD) patients. Methods: The study included 87 HD patients. Clinical characteristics, ankle-arm index (AAI), OPG and mineral markers levels were recorded. Arterial intimal calcification (AIC) and arterial medial calcification (AMC) were registered. Results: OPG levels were increased in HD patients. Patients with AIC (p = 0.006)/ AMC (p = 0.01) had higher OPG levels. OPG did not have any relation with cardiovascular diseases. OPG correlated positively with age, increased HD vintage and inversely with albumin and AAI. OPG has not been a risk factor for VC or cardiovascular disease. Conclusion: OPG rising could be a reaction in defense to vascular aggression, because OPG was associated with VC, but not with vascular disease.
引用
收藏
页码：116 / 122
页数：7
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