Synthesis, Spectroscopic Characterization and Antimicrobial Studies of Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) Melatonin Drug Complexes

被引：30

作者：

Al-Wasidi, Asma S. ^{[1
]}

Naglah, Ahmed M. ^{[2
,3
]}

Refat, Moamen S. ^{[4
,5
]}

Kalmouch, Samy M. El-Megharbel ^{[4
,6
,7
]}

Kalmouch, Atef ^{[3
]}

Moustafa, Gaber O. ^{[3
,6
,7
]}

机构：

[1] Princess Nourah Bint Abdulrahman Univ, Dept Chem, Coll Sci, Riyadh 11671, Saudi Arabia

[2] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, Drug Explorat & Dev Chair DEDC, Riyadh 11451, Saudi Arabia

[3] Natl Res Ctr, Peptide Chem Dept, Chem Ind Res Div, Cairo 12622, Egypt

[4] Taif Univ, Dept Chem, Fac Sci, Al Haweiah 21974, Taif, Saudi Arabia

[5] Port Said Univ, Dept Chem, Fac Sci, Port Said 42521, Egypt

[6] Zagazig Univ, Dept Chem, Fac Sci, Zagazig 44519, Egypt

[7] Nahda Univ, New Benisuef City 62521, Beni Sueif, Egypt

来源：

EGYPTIAN JOURNAL OF CHEMISTRY | 2020年 / 63卷 / 04期

关键词：

Melatonin drug; Synthesis; Antimicrobial; Complexes; Ligand; PERFORMANCE LIQUID-CHROMATOGRAPHY; AMINO-ACID DERIVATIVES; GROWTH IN-VIVO; GAS-CHROMATOGRAPHY; PLASMA MELATONIN; RAT PINEAL; ASSAY; BIOAVAILABILITY; INHIBITION; EYE;

D O I：

10.21608/ejchem.2020.21193.2263

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

SYNTHESIS and characterizations of new Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) melatonin drug complexes have been studied. The melatonin ligand act as a monodentate ligand through nitrogen of the deprotonated -NH pyrrole ring. This was confirmed by infrared spectra and microanalytical analysis. The magnetic moments data approved the complexity of Mn(II), Co(III), Ni(III) as a square planar and Cr(III), Fe(III) as an octahedral geometry, respectively. The biological activity of the melatonin free ligand is lower than that of the respected metal complexes. Thus, this indicates that the complexity is more effective than the antimicrobial activities of melatonin ligand.

引用

页码：1469 / 1481

页数：13

共 50 条

[1] Synthesis and Characterization of Cr (III), Mn (II), Fe (III), Co (II), Ni (II), Cu (II) and Zn (II) Complexes of 2(alpha-mercaptoacylhydrazonyl) benzimidazole
Anuradha, G. H.
Neelamma, M.
RESEARCH JOURNAL OF PHARMACEUTICAL BIOLOGICAL AND CHEMICAL SCIENCES, 2015, 6 (04): : 507 - +
[2] Physicochemical and Spectroscopic Study of Co(II), Ni(II), Cr(III), and Fe(III) Cholyltaurine Adducts
Al-Saif, F. A.
Alibrahim, K. A.
Sharshar, T.
Refat, M. S.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2017, 87 (12) : 2944 - 2950
[3] Synthesis and Characterization of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), and Zn(II) Complexes With 2,6-Pyridinedicarboxilic Acid, Chelidamic Acid, and Chelidonic Acid
Belian, Monica F.
Silva, Wagner E.
de Sa, Gilberto F.
Alves, Severino, Jr.
de Farias, Robson F.
SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY, 2014, 44 (10) : 1461 - 1463
[4] Synthesis and characterization of oxazolone complexes with Fe(III), Co(II), Ni(II), Cu(II) and Zn(II) in different counterions
Ahmed, IS
El-Mossalamy, EH
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS, 2003, 70 (02) : 679 - 686
[5] Synthesis and characterization of Cr(III), Mn(II), Co(II), Ni(II), and Cu(II) complexes with a hexadentate hemi-cage ligand formed with bipyridine
Williams, A. L.
Bhuiyan, A. A.
Turner, M. O.
Millett, F.
Durham, B.
JOURNAL OF COORDINATION CHEMISTRY, 2011, 64 (01) : 48 - 56
[6] Synthesis, characterization, theoretical and antimicrobial studies of tridentate hydrazone metal complexes of Zn(II), Cd(II), Cu(II) and Co(III)
Cao, Wei
Liu, Yaoming
Zhang, Ting
Jia, Jinping
POLYHEDRON, 2018, 147 : 62 - 68
[7] Synthesis, Characterization, Theoretical Studies, and Antimicrobial/Antitumor Potencies of Salen and Salen/Imidazole Complexes of Co (II), Ni (II), Cu (II), Cd (II), Al (III) and La (III)
Abdalla, Ehab M.
Abdel Rahman, Laila H.
Abdelhamid, Antar A.
Shehata, Mohamed R.
Alothman, Asma A.
Nafady, Ayman
APPLIED ORGANOMETALLIC CHEMISTRY, 2020, 34 (11)
[8] Ligational behaviour of lomefloxacin drug towards Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Th(IV) and UO2(VI) ions: Synthesis, structural characterization and biological activity studies
Abd El-Halim, Hanan F.
Mohamed, Gehad G.
EI-Dessouky, Maher M. I.
Mahmoud, Walaa H.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2011, 82 (01) : 8 - 19
[9] Synthesis and spectral characterization of Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) complexes produced from the template reaction of diacetyloxime and 1,2-diaminopropane
El-Tabl, AS
Kashar, TI
POLISH JOURNAL OF CHEMISTRY, 1998, 72 (03) : 519 - 526
[10] SYNTHESIS AND SPECTROSCOPIC CHARACTERIZATION OF Fe(III), Mn(II) AND Cu(II) COMPLEXES WITH N'-MALEOIL-SALICYLIC-HYDRAZID
Gondolova, G. H.
Medjidov, A. A.
Fatullayeva, P. A.
Israfilov, A. I.
CHEMICAL PROBLEMS, 2018, (01): : 44 - 50

← 1 2 3 4 5 →