Synthesis, Spectroscopic Characterization and Antimicrobial Studies of Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) Melatonin Drug Complexes

被引：30

作者：

Al-Wasidi, Asma S. ^{[1
]}

Naglah, Ahmed M. ^{[2
,3
]}

Refat, Moamen S. ^{[4
,5
]}

Kalmouch, Samy M. El-Megharbel ^{[4
,6
,7
]}

Kalmouch, Atef ^{[3
]}

Moustafa, Gaber O. ^{[3
,6
,7
]}

机构：

[1] Princess Nourah Bint Abdulrahman Univ, Dept Chem, Coll Sci, Riyadh 11671, Saudi Arabia

[2] King Saud Univ, Dept Pharmaceut Chem, Coll Pharm, Drug Explorat & Dev Chair DEDC, Riyadh 11451, Saudi Arabia

[3] Natl Res Ctr, Peptide Chem Dept, Chem Ind Res Div, Cairo 12622, Egypt

[4] Taif Univ, Dept Chem, Fac Sci, Al Haweiah 21974, Taif, Saudi Arabia

[5] Port Said Univ, Dept Chem, Fac Sci, Port Said 42521, Egypt

[6] Zagazig Univ, Dept Chem, Fac Sci, Zagazig 44519, Egypt

[7] Nahda Univ, New Benisuef City 62521, Beni Sueif, Egypt

来源：

EGYPTIAN JOURNAL OF CHEMISTRY | 2020年 / 63卷 / 04期

关键词：

Melatonin drug; Synthesis; Antimicrobial; Complexes; Ligand; PERFORMANCE LIQUID-CHROMATOGRAPHY; AMINO-ACID DERIVATIVES; GROWTH IN-VIVO; GAS-CHROMATOGRAPHY; PLASMA MELATONIN; RAT PINEAL; ASSAY; BIOAVAILABILITY; INHIBITION; EYE;

D O I：

10.21608/ejchem.2020.21193.2263

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

SYNTHESIS and characterizations of new Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) melatonin drug complexes have been studied. The melatonin ligand act as a monodentate ligand through nitrogen of the deprotonated -NH pyrrole ring. This was confirmed by infrared spectra and microanalytical analysis. The magnetic moments data approved the complexity of Mn(II), Co(III), Ni(III) as a square planar and Cr(III), Fe(III) as an octahedral geometry, respectively. The biological activity of the melatonin free ligand is lower than that of the respected metal complexes. Thus, this indicates that the complexity is more effective than the antimicrobial activities of melatonin ligand.

引用

页码：1469 / 1481

页数：13

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