In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates

被引：23
作者：
Kratky, Martin [1 ]
Vinsova, Jarmila [1 ]
Buchta, Vladimir [2 ,3 ,4 ]
机构：
[1] Charles Univ Prague, Fac Pharm, Dept Inorgan & Organ Chem, Hradec Kralove 50005, Czech Republic
[2] Charles Univ Prague, Dept Clin Microbiol, Fac Med, Hradec Kralove 50012, Czech Republic
[3] Charles Univ Prague, Univ Hosp, Hradec Kralove 50012, Czech Republic
[4] Charles Univ Prague, Fac Pharm, Dept Biol & Med Sci, Hradec Kralove 50005, Czech Republic
来源：
SCIENTIFIC WORLD JOURNAL | 2012年
关键词：
ANTIMICROBIAL ACTIVITY; AGENTS;
D O I：
10.1100/2012/290628
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The resistance to antimicrobial agents brings a need of novel antimicrobial agents. We have synthesized and found the in vitro antibacterial activity of salicylanilide esters with benzoic acid (2-(phenylcarbamoyl) phenyl benzoates) in micromolar range. They were evaluated in vitro for the activity against eight fungal and eight bacterial species. All derivatives showed a significant antibacterial activity against Gram-positive strains with minimum inhibitory concentrations >= 0.98 mu mol/L including methicillin-resistant Staphylococcus aureus strain. The most active compounds were 5-chloro-2-(3,4-dichlorophenylcarbamoyl) phenyl benzoate and 4-chloro-2-(4-(trifluoromethyl) phenylcarbamoyl) phenyl benzoate. The antifungal activity is significantly lower.
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页数：7
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