High expression of miR-210 predicts poor survival in patients with breast cancer: A meta-analysis

被引：79

作者：

Hong, Liu ^{[1
]}

Yang, Jianjun ^{[1
]}

Han, Yu ^{[2
]}

Lu, Qun ^{[3
]}

Cao, Jun ^{[3
]}

Syed, Labiq ^{[4
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp Digest Dis, Xian 710032, Shaanxi Provinc, Peoples R China

[2] Fourth Mil Med Univ, Xijing Hosp, Dept Otolaryngol, Xian 710032, Shaanxi Provinc, Peoples R China

[3] Fourth Mil Med Univ, Qindu Stomatol Coll, Xian 710032, Shaanxi Provinc, Peoples R China

[4] Johns Hopkins Univ, Sch Med, Dept Surg Oncol, Baltimore, MD 21287 USA

来源：

GENE | 2012年 / 507卷 / 02期

关键词：

Breast cancer; miR-210; Survival; CELL-PROLIFERATION; PROGNOSTIC-FACTOR; MICRORNA; HYPOXIA; MARKER; HSA-MIR-210; CORRELATE;

D O I：

10.1016/j.gene.2012.07.025

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Many microRNAs (miRNAs) exhibit altered expression levels in cancers, and they may be considered as valuable prognostic biomarkers for cancers. Here we aimed to summarize the recent advances in miR-210 involvement in human breast cancer and analyze the predicting role of miR-210 for survival. Methods: A meta-analysis was performed by searching PubMed, Cochrane Library, and Science Direct databases. Data were extracted from studies comparing survival in patients with breast cancer having higher expression of miR-210 with those having lower expression. Pooled hazard ratios (HRs) and 95% confidence intervals (CI) were calculated. Results: A total of 511 cases of breast cancer were involved for this global meta-analysis. For post-operational survival, the HR of higher miR-210 expression in breast cancer tissue was 3.39 (95% Cl: 2.04-5.63, P<0.05), which could significantly predict poorer survival. Conclusions: High expression of miR-210 might predict poor survival in patients with breast cancer. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：135 / 138

页数：4

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