Mesenteric fat-control site for bacterial translocation in colitis?

被引：58

作者：

Batra, A. ^{[1
]}

Heimesaat, M. M. ^{[2
]}

Bereswill, S. ^{[2
]}

Fischer, A. ^{[2
]}

Glauben, R. ^{[1
]}

Kunkel, D. ^{[3
,4
]}

Scheffold, A. ^{[5
]}

Erben, U. ^{[1
]}

Kuehl, A. ^{[6
]}

Loddenkemper, C. ^{[6
]}

Lehr, H-A ^{[7
]}

Schumann, M. ^{[1
]}

Schulzke, J-D ^{[1
]}

Zeitz, M. ^{[1
]}

Siegmund, B. ^{[1
]}

机构：

[1] Charite, Dept Med 1, D-13353 Berlin, Germany

[2] Charite, Inst Microbiol & Hyg, D-13353 Berlin, Germany

[3] Charite, Campus Virchow Klinikum, D-13353 Berlin, Germany

[4] Berlin Brandenburg Ctr Regenerat Therapies, Berlin, Germany

[5] Miltenyi Biotec, Bergisch Gladbach, Germany

[6] Charite, Inst Pathol, RCIS, D-13353 Berlin, Germany

[7] Univ Lausanne Hosp, Inst Pathol, Lausanne, Switzerland

来源：

MUCOSAL IMMUNOLOGY | 2012年 / 5卷 / 05期

关键词：

EPITHELIAL BARRIER FUNCTION; INFLAMMATORY-BOWEL-DISEASE; TOLL-LIKE RECEPTORS; CROHNS-DISEASE; INTESTINAL INFLAMMATION; ADIPOSE-TISSUE; LEPTIN; MICE; HOMEOSTASIS; ADIPOCYTES;

D O I：

10.1038/mi.2012.33

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In Crohn's disease bacteria could be detected in the adjacent mesenteric fat characterized by hypertrophy of unknown function. This study aimed to define effector responses of this compartment induced by bacterial translocation during intestinal inflammation. Dextran sulfate sodium-induced colitis served as a model of intestinal inflammation. Translocation of peptides and bacteria into mesenteric fat was evaluated. Innate functions of mesenteric fat and epithelium were characterized at whole tissue, cellular, and effector molecule levels. Orally applied peptides translocated in healthy wild-type (WT) mice. Bacterial translocation was not detected in healthy and acute but increased in chronic colitis. Mesenteric fat from colitic mice released elevated levels of cytokines and was infiltrated by immune cells. In MyD88(-/-) mice bacterial translocation occurred in health and increased in colitis. The exaggerated cytokine production in mesenteric fat accompanying colonic inflammation in WT mice was less distinct in MyD88(-/-) mice. In vitro studies revealed that fat not only increases cytokine production following contact with bacterial products, but also that preadipocytes are potent phagocytes. Colonic inflammation is accompanied by massive cytokine production and immune cell infiltration in adjacent adipose tissue. These effects can be considered as protective mechanisms of the mesenteric fat in the defense of bacterial translocation.

引用

页码：580 / 591

页数：12

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[11] Visceral fat adipokine secretion is associated with systemic inflammation in obese humans [J].