共 136 条
Electrochemical biosensing of uric acid: A review
被引:51
作者:
Aafria, Shatrughan
[1
]
Kumari, Preeti
[1
]
Sharma, Shikha
[1
]
Yadav, Sarita
[1
]
Batra, Bhawna
[2
]
Rana, J. S.
[2
]
Sharma, Minakshi
[1
]
机构:
[1] Maharshi Dayanand Univ, Dept Zool, Rohtak 124001, Haryana, India
[2] DCR Univ Sci &Technol, Dept Biotechnol, Sonipat, Haryana, India
关键词:
Uric acid;
Biomarker;
Amperometric;
Enzymatic Biosensors;
Non -Enzymatic Biosensors;
GLASSY-CARBON ELECTRODE;
REDUCED GRAPHENE OXIDE;
MODIFIED GOLD ELECTRODE;
ASCORBIC-ACID;
PASTE ELECTRODE;
VOLTAMMETRIC DETERMINATION;
SENSITIVE DETERMINATION;
AMPEROMETRIC BIOSENSOR;
SELECTIVE DETECTION;
POROUS CARBON;
D O I:
10.1016/j.microc.2022.107945
中图分类号:
O65 [分析化学];
学科分类号:
070302 ;
081704 ;
摘要:
Uric acid (UA) is the end product of purine derivatives in human metabolism. Both low and high levels of UA lead to a various number of disorders such as Wilson's disease, hypertension, cardiovascular diseases, kidney-related diseases. The normal range of UA in human blood serum should be fall between 0.13-0.46 mM and 1.49-4.46 mM in urine. The present review article highlights the various electrochemical biosensors developed for uric acid monitoring, with special emphasis on enzymatic and non-enzymatic methods. The enzymatic biosensors showed a concentration range between 100-107 nM and limit of detection from 0.52 to 5 x 109 nM whereas non- enzymatic biosensors showed concentration range in between 1-9 x 105 nM and limit of detection in range of 0.1-700 nM. These biosensors computed UA levels in various biological and pharmaceutical samples. Future perspectives for better improvement and commercialization of UA biosensors are also conferred.
引用
收藏
页数:15
相关论文