Effects of chronic mild stress induced depression on synaptic plasticity in mouse hippocampus

被引:47
作者
Hei, Maofang [1 ]
Chen, Peng [2 ]
Wang, Shuzhong [1 ]
Li, Xuzhao [1 ]
Xu, Mingrui [1 ]
Zhu, Xiaoyan [1 ]
Wang, Yi [3 ,4 ]
Duan, Jinyou [2 ]
Huang, Yong [1 ]
Zhao, Shanting [1 ]
机构
[1] Northwest A&F Univ, Coll Vet Med, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China
[2] Northwest A&F Univ, Coll Chem & Pharm, 22 Xinong Rd, Yangling 712100, Shaanxi, Peoples R China
[3] Hong Kong Polytech Univ, Shenzhen Res Inst, State Key Lab Chinese Med & Mol Pharmacol Incubat, Shenzhen 518057, Peoples R China
[4] Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen Key Lab Food Biol Safety Control, Shenzhen 518057, Peoples R China
关键词
Chronic mild stress; Molecular layer; Synaptic plasticity; Spine; Synapse; MESSENGER-RNA EXPRESSION; MEDIAN RAPHE NUCLEI; ANIMAL-MODEL; MAJOR DEPRESSION; RAT-BRAIN; HYDROXYLASE; MECHANISMS; PATHOPHYSIOLOGY; NEUROTOXICITY; NEUROBIOLOGY;
D O I
10.1016/j.bbr.2019.02.044
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Chronic mild stress (CMS) model is most similar to the depression human suffered in daily life. Strong evidence proved the important role of hippocampal synaptic plasticity in the mechanism of depression. This study investigated the effect of CMS on synaptic plasticity in hippocampus. Our results showed that CMS impaired spatial memory and exploring ability, disturbed the release of neurotransmitters including 5-hydroxytryptamine (5-HT) and dopamine (DA), reduced the density of synaptic vesicle in inner molecular layer, increased the number of thin spines in inner and outer molecular layer, whereas did not affect the density of spine apparatus, the above mentioned were probably related to the reduction of astrocytes and activation of microglial cells.
引用
收藏
页码:26 / 35
页数:10
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