Integrin beta 1 enhances the epithelial-mesenchymal transition in association with gefitinib resistance of non-small cell lung cancer

被引：30

作者：

Ju, Lixia ^{[1
]}

Zhou, Caicun ^{[2
,3
]}

机构：

[1] Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Tradit Chinese Med, Shanghai 200433, Peoples R China

[2] Tongji Univ, Sch Med, Shanghai Pulm Hosp, Dept Oncol, Shanghai 200433, Peoples R China

[3] Tongji Univ, Sch Med, Shanghai Pulm Hosp, Inst Canc, Shanghai 200433, Peoples R China

来源：

CANCER BIOMARKERS | 2013年 / 13卷 / 05期

关键词：

Integrin beta 1; epidermal-mesenchymal transition; EGFR TKI; resistance; non-small cell lung cancer; UP-REGULATION; SENSITIVITY; GROWTH; LINES; EGFR; DETERMINES; INHIBITORS; CARCINOMA; APOPTOSIS; KINASE;

D O I：

10.3233/CBM-130362

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have previously shown that integrin beta 1 associates with gefitinib resistance. As epithelial-mesenchymal transition (EMT) also induces gefitinib resistance in vitro, we wished to determine the relation of them in gefitinib resistance. In this study, we show that integrin beta 1 induced epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance in xenograft tumors and gefitinib-resistant NSCLC tumors acquired EMT phenotype. Furthermore, inhibition of integrin beta 1 reverses EMT, meanwhile overexpression and activation of integrin beta 1 aggravates EMT. Lastly, we further identified that integrin beta 1 enhanced EMT via FAK-AKT signaling pathway. These findings highlight a novel relation of integrin beta 1 and EMT in EGFR TKI resistant NSCLC.

引用

页码：329 / 336

页数：8

共 30 条

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