Pharmacogenetics and pharmacogenomics: are they still promising?

被引:13
作者
Pirazzoli, A [1 ]
Recchia, G [1 ]
机构
[1] GlaxoSmithKline Spa, I-37135 Verona, Italy
关键词
phamacogenetics; pharmacogenomics; clinical application; new drug discovery;
D O I
10.1016/j.phrs.2003.04.003
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
In the last several years pharmacogenetics and pharmacogenomics have attracted the interest of the scientific community and of important pharmaceutical groups. What is the consequence for medicine and for the pharmaceutical industry? What has emerged from this investment, and what can we expect for the future? As with many new technologies, pharmacogenetics and pharmacogenomics were first adapted with much enthusiasm, and then found to require time and experience, together with sustained investment, before they could take their full place in drug discovery and development. The benefits of these technologies are now emerging, however, and they have become essential tools for the pharmaceutical industry. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:357 / 361
页数:5
相关论文
共 18 条
[1]  
ANDERSON W, 2000, EFFECTS POLYMORPHISI
[2]  
*CPMP, 2002, EMEACPMP307001
[3]   The economics of gene therapy and of pharmacogenetics [J].
Danzon, P ;
Towse, A .
VALUE IN HEALTH, 2002, 5 (01) :5-13
[4]   Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment [J].
Drazen, JM ;
Yandava, CN ;
Dubé, L ;
Szczerback, N ;
Hippensteel, R ;
Pillari, A ;
Israel, E ;
Schork, N ;
Silverman, ES ;
Katz, DA ;
Drajesk, J .
NATURE GENETICS, 1999, 22 (02) :168-170
[5]   Pharmacogenetics of asthma [J].
Fenech, A ;
Hall, IP .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2002, 53 (01) :3-15
[6]   Pharmacogenetics in the laboratory and the clinic [J].
Goldstein, DB .
NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (06) :553-556
[7]   Genetic variations in HLA-B region and hypersensitivity reactions to abacavir [J].
Hetherington, S ;
Hughes, AR ;
Mosteller, M ;
Shortino, D ;
Baker, KL ;
Spreen, W ;
Lai, E ;
Davies, K ;
Handley, A ;
Dow, DJ ;
Fling, ME ;
Stocum, M ;
Bowman, C ;
Thurmond, LM ;
Roses, AD .
LANCET, 2002, 359 (9312) :1121-1122
[8]   Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy [J].
Higashi, MK ;
Veenstra, DL ;
Kondo, LML ;
Wittkowsky, AK ;
Srinouanprachanh, SL ;
Farin, FM ;
Rettie, AE .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 287 (13) :1690-1698
[9]   DRUG-RELATED MORBIDITY AND MORTALITY - A COST-OF-ILLNESS MODEL [J].
JOHNSON, JA ;
BOOTMAN, JL .
ARCHIVES OF INTERNAL MEDICINE, 1995, 155 (18) :1949-1956
[10]   Incidence of adverse drug reactions in hospitalized patients - A meta-analysis of prospective studies [J].
Lazarou, J ;
Pomeranz, BH ;
Corey, PN .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (15) :1200-1205