共 37 条
Type I Interferon and NF-κB Activation Elicited by Herpes Simplex Virus gH/gL via αvβ3 Integrin in Epithelial and Neuronal Cell Lines
被引:43
作者:

Gianni, Tatiana
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Alma Mater Studiorum Univ Bologna, Dept Expt Diagnost & Specialty Med, Bologna, Italy Alma Mater Studiorum Univ Bologna, Dept Expt Diagnost & Specialty Med, Bologna, Italy

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Campadelli-Fiume, Gabriella
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Alma Mater Studiorum Univ Bologna, Dept Expt Diagnost & Specialty Med, Bologna, Italy Alma Mater Studiorum Univ Bologna, Dept Expt Diagnost & Specialty Med, Bologna, Italy
机构:
[1] Alma Mater Studiorum Univ Bologna, Dept Expt Diagnost & Specialty Med, Bologna, Italy
关键词:
TOLL-LIKE RECEPTOR-2;
DENDRITIC CELLS;
LIPID RAFTS;
POLIOVIRUS RECEPTOR;
INFECTION;
ENTRY;
PROTEIN;
TLR2;
REPLICATION;
RECOGNITION;
D O I:
10.1128/JVI.01894-13
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
alpha v beta 3 integrin represents a novel sensing system which detects herpes simplex virus (HSV) and bacterial constituents. In cooperation with Toll-like receptor 2 (TLR2), it elicits an innate response that leads to activation of type I interferon (IFN), NF-kappa B, and a specific set of cytokines. We report that this defensive branch is functional in cells which represent experimental models of epithelial, including keratinocytic, and neuronal cells. These are the major targets of HSV in vivo. HSV entered the three cell lines via distinct routes. Hence, the defensive response was independent of the route of virus entry. Soluble gH/gL sufficed to elicit type I IFN and NF-kappa B activation and represents the viral pathogen-associated molecular pattern (PAMP) of this defense system.
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页码:13911 / 13916
页数:6
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共 37 条
[1]
Herpes simplex virus disrupts NF-κB regulation by blocking its recruitment on the IκBα promoter and directing the factor on viral genes
[J].
Amici, C
;
Rossi, A
;
Costanzo, A
;
Ciafrè, S
;
Marinari, B
;
Balsamo, M
;
Levrero, M
;
Santoro, MG
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
2006, 281 (11)
:7110-7117

Amici, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Rossi, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Costanzo, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Ciafrè, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Marinari, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Balsamo, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Levrero, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

Santoro, MG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy
[2]
Polymorphisms in TLR2 are associated with increased viral shedding and lesional rate in patients with genital herpes simplex virus type 2 infection
[J].
Bochud, Pierre-Yves
;
Magaret, Amalia S.
;
Koelle, David M.
;
Aderem, Alan
;
Wald, Anna
.
JOURNAL OF INFECTIOUS DISEASES,
2007, 196 (04)
:505-509

Bochud, Pierre-Yves
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Inst Syst Biol, Seattle, WA 98103 USA

Magaret, Amalia S.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Inst Syst Biol, Seattle, WA 98103 USA

Koelle, David M.
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Inst Syst Biol, Seattle, WA 98103 USA

Aderem, Alan
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Inst Syst Biol, Seattle, WA 98103 USA

Wald, Anna
论文数: 0 引用数: 0
h-index: 0
机构: Univ Washington, Inst Syst Biol, Seattle, WA 98103 USA
[3]
Regulation of alphaherpesvirus infections by the ICP0 family of proteins
[J].
Boutell, Chris
;
Everett, Roger D.
.
JOURNAL OF GENERAL VIROLOGY,
2013, 94
:465-481

论文数: 引用数:
h-index:
机构:

Everett, Roger D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Glasgow, Ctr Virus Res, MRC, Glasgow G11 5JR, Lanark, Scotland Univ Glasgow, Ctr Virus Res, MRC, Glasgow G11 5JR, Lanark, Scotland
[4]
The ectodomain of a novel member of the immunoglobulin subfamily related to the poliovirus receptor has the attributes of a bona fide receptor for herpes simplex virus types 1 and 2 in human cells
[J].
Cocchi, F
;
Menotti, L
;
Mirandola, P
;
Lopez, M
;
Campadelli-Fiume, G
.
JOURNAL OF VIROLOGY,
1998, 72 (12)
:9992-10002

Cocchi, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, I-40126 Bologna, Italy

Menotti, L
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, I-40126 Bologna, Italy

Mirandola, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, I-40126 Bologna, Italy

Lopez, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, I-40126 Bologna, Italy

Campadelli-Fiume, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, I-40126 Bologna, Italy
[5]
Human cytomegalovirus activates inflammatory cytokine responses via CD14 and toll-like receptor 2
[J].
Compton, T
;
Kurt-Jones, EA
;
Boehme, KW
;
Belko, J
;
Latz, E
;
Golenbock, DT
;
Finberg, RW
.
JOURNAL OF VIROLOGY,
2003, 77 (08)
:4588-4596

Compton, T
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Wisconsin, Madison Med Sch, McArdle Lab Canc Res, Madison, WI 53706 USA Univ Wisconsin, Madison Med Sch, McArdle Lab Canc Res, Madison, WI 53706 USA

Kurt-Jones, EA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Madison Med Sch, McArdle Lab Canc Res, Madison, WI 53706 USA

Boehme, KW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Madison Med Sch, McArdle Lab Canc Res, Madison, WI 53706 USA

Belko, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Madison Med Sch, McArdle Lab Canc Res, Madison, WI 53706 USA

论文数: 引用数:
h-index:
机构:

Golenbock, DT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Madison Med Sch, McArdle Lab Canc Res, Madison, WI 53706 USA

Finberg, RW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Wisconsin, Madison Med Sch, McArdle Lab Canc Res, Madison, WI 53706 USA
[6]
Resistance to HSV-1 infection in the epithelium resides with the novel innate sensor, IFI-16
[J].
Conrady, C. D.
;
Zheng, M.
;
Fitzgerald, K. A.
;
Liu, C.
;
Carr, D. J. J.
.
MUCOSAL IMMUNOLOGY,
2012, 5 (02)
:173-183

Conrady, C. D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol, Oklahoma City, OK 73190 USA Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol, Oklahoma City, OK 73190 USA

Zheng, M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Oklahoma City, OK USA Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol, Oklahoma City, OK 73190 USA

Fitzgerald, K. A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Massachusetts, Sch Med, Div Infect Dis & Immunol, Worcester, MA USA Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol, Oklahoma City, OK 73190 USA

Liu, C.
论文数: 0 引用数: 0
h-index: 0
机构:
NYU, Sch Med, Dept Orthoped Surg & Cell Biol, New York, NY USA Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol, Oklahoma City, OK 73190 USA

Carr, D. J. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol, Oklahoma City, OK 73190 USA
Univ Oklahoma, Hlth Sci Ctr, Dept Ophthalmol, Oklahoma City, OK USA Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol, Oklahoma City, OK 73190 USA
[7]
Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor
[J].
Geraghty, RJ
;
Krummenacher, C
;
Cohen, GH
;
Eisenberg, RJ
;
Spear, PG
.
SCIENCE,
1998, 280 (5369)
:1618-1620

Geraghty, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Northwestern Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA

Krummenacher, C
论文数: 0 引用数: 0
h-index: 0
机构: Northwestern Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA

Cohen, GH
论文数: 0 引用数: 0
h-index: 0
机构: Northwestern Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA

Eisenberg, RJ
论文数: 0 引用数: 0
h-index: 0
机构: Northwestern Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA

Spear, PG
论文数: 0 引用数: 0
h-index: 0
机构:
Northwestern Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA Northwestern Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA
[8]
Entry of herpes simplex virus mediated by chimeric forms of nectinl retargeted to endosomes or to lipid rafts occurs through acidic endosomes
[J].
Gianni, T
;
Campadelli-Fiume, G
;
Menotti, L
.
JOURNAL OF VIROLOGY,
2004, 78 (22)
:12268-12276

Gianni, T
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, I-40126 Bologna, Italy Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, I-40126 Bologna, Italy

Campadelli-Fiume, G
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, I-40126 Bologna, Italy Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, I-40126 Bologna, Italy

Menotti, L
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, I-40126 Bologna, Italy Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, I-40126 Bologna, Italy
[9]
αvβ3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1
[J].
Gianni, Tatiana
;
Leoni, Valerio
;
Chesnokova, Liudmila S.
;
Hutt-Fletcher, Lindsey M.
;
Campadelli-Fiume, Gabriella
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2012, 109 (48)
:19792-19797

Gianni, Tatiana
论文数: 0 引用数: 0
h-index: 0
机构:
Alma Mater Studiorum Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy Alma Mater Studiorum Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy

论文数: 引用数:
h-index:
机构:

Chesnokova, Liudmila S.
论文数: 0 引用数: 0
h-index: 0
机构:
Louisiana State Univ, Hlth Sci Ctr, Ctr Mol & Tumor Virol, Dept Microbiol & Immunol, Shreveport, LA 71130 USA
Louisiana State Univ, Hlth Sci Ctr, Feist Weiller Canc Ctr, Shreveport, LA 71130 USA Alma Mater Studiorum Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy

Hutt-Fletcher, Lindsey M.
论文数: 0 引用数: 0
h-index: 0
机构:
Louisiana State Univ, Hlth Sci Ctr, Ctr Mol & Tumor Virol, Dept Microbiol & Immunol, Shreveport, LA 71130 USA
Louisiana State Univ, Hlth Sci Ctr, Feist Weiller Canc Ctr, Shreveport, LA 71130 USA Alma Mater Studiorum Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy

Campadelli-Fiume, Gabriella
论文数: 0 引用数: 0
h-index: 0
机构:
Alma Mater Studiorum Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy Alma Mater Studiorum Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy
[10]
αVβ3-Integrin Relocalizes nectin1 and Routes Herpes Simplex Virus to Lipid Rafts
[J].
Gianni, Tatiana
;
Campadelli-Fiume, Gabriella
.
JOURNAL OF VIROLOGY,
2012, 86 (05)
:2850-2855

Gianni, Tatiana
论文数: 0 引用数: 0
h-index: 0
机构:
Alma Mater Studiorum Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, Bologna, Italy Alma Mater Studiorum Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, Bologna, Italy

Campadelli-Fiume, Gabriella
论文数: 0 引用数: 0
h-index: 0
机构:
Alma Mater Studiorum Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, Bologna, Italy Alma Mater Studiorum Univ Bologna, Dept Expt Pathol, Sect Microbiol & Virol, Bologna, Italy