First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)"

被引：52

作者：

Jakob, Carolin E. M. ^{[1
,2
]}

Borgmann, Stefan ^{[3
]}

Duygu, Fazilet ^{[4
]}

Behrends, Uta ^{[2
,5
,6
]}

Hower, Martin ^{[7
]}

Merle, Uta ^{[8
]}

Friedrichs, Anette ^{[9
]}

Tometten, Lukas ^{[10
]}

Hanses, Frank ^{[11
]}

Jung, Norma ^{[1
]}

Rieg, Siegbert ^{[12
]}

Wille, Kai ^{[13
]}

Gruener, Beate ^{[14
]}

Klinker, Hartwig ^{[15
]}

Gersbacher-Runge, Nicole ^{[16
]}

Hellwig, Kerstin ^{[17
]}

Eberwein, Lukas ^{[18
]}

Dolff, Sebastian ^{[19
]}

Rauschning, Dominic ^{[20
]}

von Bergwelt-Baildon, Michael ^{[21
,22
,23
]}

Lanznaster, Julia ^{[24
]}

Strauss, Richard ^{[25
]}

Trauth, Janina ^{[26
]}

de With, Katja ^{[27
]}

Ruethrich, Maria ^{[28
]}

Lueck, Catherina ^{[29
]}

Nattermann, Jacob ^{[2
,30
]}

Tscharntke, Lene ^{[1
]}

Pilgram, Lisa ^{[32
]}

Fuhrmann, Sandra ^{[1
]}

Classen, Annika ^{[1
,2
]}

Stecher, Melanie ^{[1
,2
]}

Schons, Maximilian ^{[1
]}

Spinner, Christoph ^{[2
,31
]}

Vehreschild, Joerg Janne ^{[1
,2
,32
]}

机构：

[1] Univ Cologne, Univ Hosp Cologne, Dept Internal Med 1, Cologne, Germany

[2] German Ctr Infect Res DZIF, Braunschweig, Germany

[3] Ingolstadt Hosp, Dept Infect Dis & Infect Control, Ingolstadt, Germany

[4] Goethe Univ Frankfurt, Dept Internal Med, Infect Dis, Frankfurt, Germany

[5] Tech Univ Munich, Childrens Hosp, Munich, Germany

[6] Helmholtz Zentrum Muenchen, Res Unit Gene Vectors, Munich, Germany

[7] Hosp Dortmund gGmbH, Clin Pneumol Infectiol Internal Med & Intens Care, Dortmund, Germany

[8] Heidelberg Univ Hosp, Dept Gastroenterol & Infectiol, Heidelberg, Germany

[9] Univ Hosp Schleswig Holstein, Dept Internal Med, Kiel, Germany

[10] Klinikum Ernst von Bergmann, Dept Gastroenterol & Infectiol, Potsdam, Germany

[11] Univ Hosp Regensburg, Emergency Dept, Regensburg, Germany

[12] Univ Freiburg, Dept Med 2, Freiburg, Germany

[13] Univ Bochum, Univ Clin Haematol Oncol Haemostaseol & Palliat C, Minden, Germany

[14] Univ Hosp Ulm, Dept Internal Med 3, Div Infect Dis, Ulm, Germany

[15] Univ Wurzburg, Dept Med 2, Div Infect Dis, Med Ctr, Wurzburg, Germany

[16] Ctr Infectiol Berlin Prenzlauer Berg, Berlin, Germany

[17] Ruhr Univ Bochum, Dept Neurol, Katholisches Klinikum Bochum, Bochum, Germany

[18] Klinikum Leverkusen gGmbH, Dept Internal Med 4, Leverkusen, Germany

[19] Univ Duisburg Essen, Univ Hosp Essen, Dept Infect Dis, Essen, Germany

[20] Bundeswehr Cent Hosp, Koblenz, Germany

[21] Ludwig Maximilians Univ Munchen, Dept Internal Med 3, Munich, Germany

[22] German Canc Consortium DKTK, Partner Site Munich, Munich, Germany

[23] Bavarian Ctr Canc Res BZKF, Munich, Germany

[24] Hosp Passau, Med Clin 2, Passau, Germany

[25] Univ Hosp Erlangen, Dept Med 1, Erlangen, Germany

[26] Univ Hosp Giessen, Med Clin 2, Giessen, Germany

[27] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Div Infect Dis, Dresden, Germany

[28] Univ Hosp Jena, Dept Internal Med 2, Jena, Germany

[29] Hannover Med Sch, Dept Haematol Haemostasis Oncol & Stem Cell Trans, Hannover, Germany

[30] UKB Univ Hosp Bonn, Dept Internal Med 1, Bonn, Germany

[31] Tech Univ Munich, Univ Hosp Rechts Isar, Sch Med, Dept Internal Med 2, Munich, Germany

[32] Goethe Univ Frankfurt, Dept Internal Med Hematol & Oncol, Frankfurt, Germany

来源：

INFECTION | 2021年 / 49卷 / 01期

关键词：

SARS-CoV-2; COVID-19; LEOSS; Cohort study; NEW-YORK-CITY; CLINICAL CHARACTERISTICS; CORONAVIRUS; COVID-19; OUTCOMES; WUHAN;

D O I：

10.1007/s15010-020-01499-0

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Purpose Knowledge regarding patients' clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19. Methods Sociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logistic regression models. Results We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66-85 years (39.6%; 500/2,155). The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46-65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25-2.42,p = 0.001; 66-85 years: aOR 1.93, 95% CI 1.36-2.74,p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49-3.81,p < 0.001 vs. individuals aged 26-45 years], male sex (aOR 1.23, 95% CI 1.01-1.50,p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09-1.72,p = 0.007), and diabetes (aOR 1.33, 95% CI 1.04-1.69,p = 0.023) were associated with complicated stages of COVID-19 at diagnosis. Conclusion The LEOSS cohort identified age, cardiovascular disease, diabetes and male sex as risk factors for complicated disease stages at SARS-CoV-2 diagnosis, thus confirming previous data. Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required.

引用

页码：63 / 73

页数：11

共 27 条

[11] Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection [J].

Henry, Brandon Michael ;

Lippi, Giuseppe .

INTERNATIONAL UROLOGY AND NEPHROLOGY, 2020, 52 (06) :1193-1194

[12] Coronavirus Disease-19: The First 7,755 Cases in the Republic of Korea [J].

Jeong, Eun Kyeong ;

Park, Ok ;

Park, Young Joon ;

Park, Shin Young ;

Kim, Young-Man ;

Kim, Jieun ;

Jo, Joongho ;

Kim, Jungwoo ;

Kim, Taeyoung ;

Kweon, Sanghui ;

Woo, Yeonhee ;

Yum, Minwoo ;

Kim, Eunyoung ;

Gwack, Jin ;

Lee, Jin ;

Park, Eunmi ;

Kim, Seong Sun ;

Hyun, Junghee ;

Ryu, Boyeong ;

Jang, Yoon Suk ;

Kim, Hwami ;

Jin, Yeowon ;

Lee, Hyeyoung ;

Lee, Sangeun ;

Shin, Seung Hwan ;

Choi, Seung Woo ;

Ko, Daehyeon ;

Yi, Seonju ;

Kim, Hee Kyoung ;

Kim, Dongwook ;

Jeon, Byoung-Hak ;

Kim, Miyoung ;

Choi, Si Won ;

Lee, Jung Hyun ;

Park, Jae Kyung ;

Kim, Unna ;

Choe, Young June .

OSONG PUBLIC HEALTH AND RESEARCH PERSPECTIVES, 2020, 11 (02) :85-90

[13] Incidence, clinical outcomes, and transmission dynamics of severe coronavirus disease 2019 in California and Washington: prospective cohort study [J].

Lewnard, Joseph A. ;

Liu, Vincent X. ;

Jackson, Michael L. ;

Schmidt, Mark A. ;

Jewell, Britta L. ;

Flores, Jean P. ;

Jentz, Chris ;

Northrup, Graham R. ;

Mahmud, Ayesha ;

Reingold, Arthur L. ;

Petersen, Maya ;

Jewell, Nicholas P. ;

Young, Scott ;

Bellows, Jim .

BMJ-BRITISH MEDICAL JOURNAL, 2020, 369

[14] Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults A Living Systematic Review [J].

Mackey, Katherine ;

King, Valerie J. ;

Gurley, Susan ;

Kiefer, Michael ;

Liederbauer, Erik ;

Vela, Kathryn ;

Sonnen, Payten ;

Kansagara, Devan .

ANNALS OF INTERNAL MEDICINE, 2020, 173 (03) :195-+

[15] Renin-Angiotensin-Aldosterone System Blockers and the Risk of Covid-19 [J].

Mancia, Giuseppe ;

Rea, Federico ;

Ludergnani, Monica ;

Apolone, Giovanni ;

Corrao, Giovanni .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (25) :2431-2440

[16] High mortality rates for SARS-CoV-2 infection in patients with pre-existing chronic liver disease and cirrhosis: Preliminary results from an international registry [J].

Moon, Andrew M. ;

Webb, Gwilym J. ;

Aloman, Costica ;

Armstrong, Matthew J. ;

Cargill, Tamsin ;

Dhanasekaran, Renumathy ;

Genesca, Joan ;

Gill, Upkar S. ;

James, Theodore W. ;

Jones, Patricia D. ;

Marshall, Aileen ;

Mells, George ;

Perumalswami, Ponni V. ;

Qi, Xiaolong ;

Su, Feng ;

Ufere, Nneka N. ;

Barnes, Eleanor ;

Barritt, A. Sidney ;

Marjot, Thomas .

JOURNAL OF HEPATOLOGY, 2020, 73 (03) :705-708

[17]

Petrilli CM, 2010, FACTORS ASS HOSPITAL, DOI 10.1101/2020.04.08.20057794

[18] Renin-Angiotensin-Aldosterone System Inhibitors and Risk of Covid-19 [J].

Reynolds, Harmony R. ;

Adhikari, Samrachana ;

Pulgarin, Claudia ;

Troxel, Andrea B. ;

Iturrate, Eduardo ;

Johnson, Stephen B. ;

Hausvater, Anais ;

Newman, Jonathan D. ;

Berger, Jeffrey S. ;

Bangalore, Sripal ;

Katz, Stuart D. ;

Fishman, Glenn I. ;

Kunichoff, Dennis ;

Chen, Yu ;

Ogedegbe, Gbenga ;

Hochman, Judith S. .

NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (25) :2441-2448

[19] Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area [J].

Richardson, Safiya ;

Hirsch, Jamie S. ;

Narasimhan, Mangala ;

Crawford, James M. ;

McGinn, Thomas ;

Davidson, Karina W. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (20) :2052-2059

[20] Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China [J].

Wang, Dawei ;

Hu, Bo ;

Hu, Chang ;

Zhu, Fangfang ;

Liu, Xing ;

Zhang, Jing ;

Wang, Binbin ;

Xiang, Hui ;

Cheng, Zhenshun ;

Xiong, Yong ;

Zhao, Yan ;

Li, Yirong ;

Wang, Xinghuan ;

Peng, Zhiyong .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 323 (11) :1061-1069

← 1 2 3 →