Kinetic Modeling of the Gas Antisolvent Process for Synthesis of 5-Fluorouracil Nanoparticles

被引：18
作者：
Esfandiari, Nadia [1 ]
Ghoreishi, Seyyed M. [1 ]
机构：
[1] Isfahan Univ Technol, Dept Chem Engn, Esfahan 8415683111, Iran
来源：
CHEMICAL ENGINEERING & TECHNOLOGY | 2014年 / 37卷 / 01期
关键词：
5-Fluorouracil; Gas antisolvent process; Kinetics; Modeling; Supercritical carbon dioxide; SUPERCRITICAL SOLUTION; RAPID EXPANSION; CARBON-DIOXIDE; PRECIPITATION; RECRYSTALLIZATION; MICRONIZATION; CRYSTALLIZATION; MICROPARTICLES; INJECTION;
D O I：
10.1002/ceat.201300431
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
Mathematical modeling for 5-fluorouracil (5-FU) nanoparticle synthesis via gas antisolvent (GAS) process was investigated. 5-FU was precipitated from a dimethyl sulfoxide (DMSO) solution using CO2 as antisolvent. The particle size was controlled by nucleation and growth rates, therefore, the kinetic modeling study is essential. Thermodynamic modeling was applied to determine optimal operating conditions for experimental 5-FU synthesis. Kinetic parameters were evaluated by fitting the particle size distribution predicted by the model to experimental data. The experimental and modeling results indicated that the particle size decreased with increasing the antisolvent addition rate.
引用
收藏
页码：73 / 80
页数：8
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