Di and tripeptides from marine sources can target adipogenic process and contribute to decrease adipocyte number and functions

被引：19

作者：

Ben Henda, Yesmine ^{[1
]}

Laamari, Mariem ^{[1
]}

Lanneluc, Isabelle ^{[1
]}

Travers, Marie-Agnes ^{[2
]}

Agogue, Helene ^{[3
]}

Arnaudin, Ingrid ^{[1
]}

Bridiau, Nicolas ^{[1
]}

Maugard, Thierry ^{[1
]}

Piot, Jean-Marie ^{[1
]}

Sannier, Frederic ^{[1
]}

Bordenave-Juchereau, Stephanie ^{[1
]}

机构：

[1] Univ La Rochelle, UFR Sci Technol Sante, Lab LIENSs, CNRS,UMR 7266,Approches Mol,Environm Sante, F-17042 La Rochelle 1, France

[2] IFREMER, SG2M LGPMM, Lab Genet & Pathol Mollusques Marins, F-17390 La Tremblade, France

[3] Univ La Rochelle, Mol Core Facil, Lab LIENSs, CNRS,UMR7266, F-17000 La Rochelle, France

来源：

JOURNAL OF FUNCTIONAL FOODS | 2015年 / 17卷

关键词：

Bioactive peptides; Obesity; Human white pre-adipocytes'; Proliferation; Differentiation; Adipocyte differentiation markers; PROTEIN HYDROLYSATE; DIFFERENTIATION; 3T3-L1; CELLS; PREADIPOCYTES; APOPTOSIS; PEPTIDES; OBESITY; CYCLE; ACID;

D O I：

10.1016/j.jff.2015.04.050

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The effect of 11 marine-derived cryptides was investigated on proliferation, differentiation and maturation of human white pre-adipocytes (HWP). They were all formerly identified as potent Angiotensin-Converting-Enzyme inhibitors. Val-Trp (VW), Val-Tyr (VY), Lys-Tyr (KY), Lys-Trp (KW), Ile-Tyr (IY), Ala-Pro (AP), Val-Ile-Tyr (VIY), Leu-Lys-Pro (LKP), Gly-Pro-Leu (GPL), Ala-Lys-Lys (AKK) and Val-Ala-Pro (VAP) were previously found in fish products and co-products as well as other marine resources like wakame. Treatment with AP, VAP and AKK greatly affected viability of HWP during the proliferation period while KW and VW treatment reduced the number of viable cells during the differentiation stage. A GPL and IY incubation during the differentiation stage allowed the decrease of their final lipid content, of the GPDH activity and of the mRNA level of adipocyte markers (aP2, GLUT4, LPL and AGT). Moreover, a down regulation of both PPAR gamma and C/EBP alpha expression, two key regulators of adipogenesis, was observed. These findings indicate that small bioactive peptides from marine protein hydrolysates can target adipogenesis and thus could regulate energy metabolism disorders. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：1 / 10

页数：10

共 25 条

[1] Measuring Angiotensin-I Converting Enzyme Inhibitory Activity by Micro Plate Assays: Comparison Using Marine Cryptides and Tentative Threshold Determinations with Captopril and Losartan [J].