Synthesis of 4′-C-alkylated-5-iodo-2′-deoxypyrimidine nucleosides

被引：2
|
作者：
Strittmatter, Tobias
Aschenbrenner, Joos
Hardt, Norman
Marx, Andreas [1 ]
机构：
[1] Univ Konstanz, Dept Chem, Univ Str 10, D-78457 Constance, Germany
来源：
ARKIVOC | 2013年
关键词：
DNA replication; nucleoside analogues; 4 '-C-alkylation; antiviral agents; carbohydrate; halogenation; SINGLE-NUCLEOTIDE DISCRIMINATION; POLYMERASE-CHAIN REACTIONS; ASYMMETRIC-SYNTHESIS; DNA-POLYMERASES; PROBES; ANALOGS; CONSTRAINTS; NUCLEOBASE; AGENTS; BLOCK;
D O I：
10.3998/ark.5550190.0014.206
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Starting from available ribose-building blocks, the 4'-C-methyl-, 4'-C-ethyl- and the new 4'-C-propyl-substituted deoxyuridines were synthesized. Afterwards we converted 4'-C-alkylated-2'-deoxyuridines into the corresponding 4'-C-alkylated-5-iodo-2'-deoxyuridines 3a-c and those in turn into the 4'-C-alkylated-5-iodo-2'-deoxycytidines 4a-c.
引用
收藏
页码：46 / 59
页数：14
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