Effects of initiation of continuous renal replacement therapy on hemodynamics in a pediatric animal model

被引：12

作者：

López-Herce, J ^{[1
]}

Rupérez, M ^{[1
]}

Sánchez, C ^{[1
]}

Garcíia, C ^{[1
]}

Garcíia, E ^{[1
]}

机构：

[1] Hosp Gen Gregorio Maranon, Pediat Intens Care Unit, Secc Cuidados Intens Pediat, Madrid 28009, Spain

来源：

RENAL FAILURE | 2006年 / 28卷 / 02期

关键词：

continuous renal replacement therapy; children; hemofiltration; hemodynamic; cardiac output; acute renal failure;

D O I：

10.1080/08860220500531146

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

There are no studies analyzing the initial hemodynamic impact of continuous renal replacement therapy (CRRT) in children. We have performed a prospective observational study in 34 immature Maryland pigs to analyze the initial hemodynamic changes during venovenous CRRT. The heart rate, blood pressure, central venous pressure (CVP), pulmonary arterial occlusion pressure (PAOP), pulmonary capillary wedge pressure, temperature, and cardiac output (CO), simultaneously by pulmonary arterial thermodilution and femoral arterial thermodilution, were measured at 30-min intervals during 2 h. Venovenous CRRT induced an initial significant diminution of volemic hemodynamic parameters (intrathoracic blood volume, global end-diastolic volume, stroke volume index, PAOP, and CVP). Simultaneously, a significant increase in systemic vascular resistance index and left ventricular contractility, and a decrease in CO, was observed. We conclude that CRRT in a pediatric animal model induces initial hypovolemia, and a systemic cardiovascular response with vasoconstriction and increase in ventricular contractility.

引用

页码：171 / 176

页数：6