Diversity and function of presynaptic calcium channels in the brain

被引:119
|
作者
Reuter, H
机构
[1] Pharmakologisches Institut, Universität Bern, GH-3010 Bern
关键词
D O I
10.1016/S0959-4388(96)80116-4
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Calcium channels in presynaptic nerve terminals are essential for neurotransmitter release, and current research has provided evidence for the involvement of a multitude of Ca2+ channel types. The diversity of Ca2+ channel structure and distribution in the brain suggests specific functional roles. Modulation by interaction with other proteins and/or by phosphorylation/dephosphorylation reactions enhances the regulatory impact of these channels on brain function.
引用
收藏
页码:331 / 337
页数:7
相关论文
共 50 条
  • [41] Effect of spatial arrangement of presynaptic calcium channels on the calcium current cooperativity of neurotransmitter release
    Victor Matveev
    Richard Betram
    Arthur Sherman
    BMC Neuroscience, 12 (Suppl 1)
  • [42] Presynaptic Protein Synthesis in Brain Function and Disease
    Castillo, Pablo E.
    Jung, Hosung
    Klann, Eric
    Riccio, Antonella
    JOURNAL OF NEUROSCIENCE, 2023, 43 (45): : 7483 - 7488
  • [43] Endothelial calcium dynamics, connexin channels and blood-brain barrier function
    De Bock, Marijke
    Wang, Nan
    Decrock, Elke
    Bol, Melissa
    Gadicherla, Ashish K.
    Culot, Maxime
    Cecchelli, Romeo
    Bultynck, Geert
    Leybaert, Luc
    PROGRESS IN NEUROBIOLOGY, 2013, 108 : 1 - 20
  • [44] Functional interactions between presynaptic calcium channels and the neurotransmitter release machinery
    Spafford, JD
    Zamponi, GW
    CURRENT OPINION IN NEUROBIOLOGY, 2003, 13 (03) : 308 - 314
  • [45] Rapid inactivation of presynaptic calcium channels via a G protein pathway
    Stanley, EF
    Sheng, ZH
    Mirotznik, RR
    BIOPHYSICAL JOURNAL, 1998, 74 (02) : A139 - A139
  • [46] Calcium channels in Xenopus spinal neurons differ in somas and presynaptic terminals
    Li, WY
    Thaler, C
    Brehm, P
    JOURNAL OF NEUROPHYSIOLOGY, 2001, 86 (01) : 269 - 279
  • [47] Pharmacologically distinct presynaptic calcium channels in cerebellar excitatory and inhibitory synapses
    Doroshenko, PA
    Woppmann, A
    Miljanich, G
    Augustine, GJ
    NEUROPHARMACOLOGY, 1997, 36 (06) : 865 - 872
  • [48] FMRP regulates presynaptic localization of neuronal voltage gated calcium channels
    Ferron, Laurent
    Novazzi, Cesare G.
    Pilch, Kjara S.
    Moreno, Cristian
    Ramgoolam, Krishma
    Dolphin, Annette C.
    NEUROBIOLOGY OF DISEASE, 2020, 138
  • [49] Effects of external pH variations on brain presynaptic sodium and calcium channels;: Repercussion on the evoked release of amino acid neurotransmitters
    Sitges, M
    Rodríguez, RM
    NEUROCHEMICAL RESEARCH, 1998, 23 (04) : 477 - 485
  • [50] Molecular determinants of G protein regulation of presynaptic calcium channels.
    Zamponi, GW
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1997, 356 (04) : 94 - 94