Masked Mycotoxins Are Efficiently Hydrolyzed by Human Colonic Microbiota Releasing Their Aglycones

被引：162

作者：

Dall'Erta, Andrea ^{[1
]}

Cirlini, Martina ^{[1
]}

Dall'Asta, Margherita ^{[1
]}

Del Rio, Daniele ^{[1
,2
]}

Galaverna, Gianni ^{[1
]}

Dall'Asta, Chiara ^{[1
,2
]}

机构：

[1] Univ Parma, Dept Food Sci, I-43100 Parma, Italy

[2] Interlab Grp, Bioact & Hlth LS9, Parma, Italy

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2013年 / 26卷 / 03期

关键词：

ZEARALENONE-GLYCOSIDE; DIGESTION; DEOXYNIVALENOL-3-GLUCOSIDE; FUMONISINS; METABOLISM; HIDDEN;

D O I：

10.1021/tx300438c

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fusarium mycotoxins are secondary metabolites produced by Fusarium spp. in cereals. Among them, deoxynivalenol (DON) and zearalenone (ZEN) are widespread worldwide contaminants of cereal commodities and are ranked as the most important chronic dietary risk factors. Their conjugates, known as masked mycotoxins, have been described but are still not accounted for in risk assessment studies. This study demonstrates for the first time that DON and ZEN are effectively deconjugated by the human colonic microbiota, releasing their toxic aglycones and generating yet unidentified catabolites. For this reason, masked mycotoxins should be considered when evaluating population exposure.

引用

收藏

页码：305 / 312

页数：8

相关论文

共 22 条

[1] Scientific Opinion on the risks for public health related to the presence of zearalenone in food EFSA Panel on Contaminants in the Food Chain [J].

Alexander, Jan ;

Benford, Diane ;

Boobis, Alan ;

Ceccatelli, Sandra ;

Cottrill, Bruce ;

Cravedi, Jean-Pierre ;

Di Domenico, Alessandro ;

Doerge, Daniel ;

Dogliotti, Eugenia ;

Edler, Lutz ;

Fanner, Peter ;

Filipic, Metka ;

Fink-Gremmels, Johanna ;

Fuerst, Peter ;

Guerin, Thierry ;

Knutsen, Helle Katrine ;

Machala, Miroslav ;

Mutti, Antonio ;

Schlatter, Josef ;

Rose, Martin ;

van Leeuwen, Rolaf .

EFSA JOURNAL, 2011, 9 (06)

[2] Preparation and characterization of the conjugated Fusarium mycotoxins zearalenone-4O-b-D-glucopyranoside, α-zearalenol-4O-b-D-glucopyranoside and β-zearalenol-4O-b-D-glucopyranoside by MS/MS and two-dimensional NMR [J].

Berthiller, F. ;

Hametner, C. ;

Krenn, P. ;

Schweiger, W. ;

Ludwig, R. ;

Adam, G. ;

Krska, R. ;

Schuhmacher, R. .

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2009, 26 (02) :207-213

[3] Masked mycotoxins: A review [J].

Berthiller, Franz ;

Crews, Colin ;

Dall'Asta, Chiara ;

De Saeger, Sarah ;

Haesaert, Geert ;

Karlovsky, Petr ;

Oswald, Isabelle P. ;

Seefelder, Walburga ;

Speijers, Gerrit ;

Stroka, Joerg .

MOLECULAR NUTRITION & FOOD RESEARCH, 2013, 57 (01) :165-186

[4] Hydrolytic fate of deoxynivalenol-3-glucoside during digestion [J].

Berthiller, Franz ;

Krska, Rudolf ;

Domig, Konrad J. ;

Kneifel, Wolfgang ;

Juge, Nathalie ;

Schuhmacher, Rainer ;

Adam, Gerhard .

TOXICOLOGY LETTERS, 2011, 206 (03) :264-267

[5] Updated bioavailability and 48 h excretion profile of flavan-3-ols from green tea in humans [J].

Calani, Luca ;

Del Rio, Daniele ;

Callegari, Maria Luisa ;

Morelli, Lorenzo ;

Brighenti, Furio .

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION, 2012, 63 (05) :513-521

[6] APPLICATIONS OF NEXT-GENERATION SEQUENCING The human microbiome: at the interface of health and disease [J].

Cho, Ilseung ;

Blaser, Martin J. .

NATURE REVIEWS GENETICS, 2012, 13 (04) :260-270

[7] In Vitro Digestion Assay for Determination of Hidden Fumonisins in Maize [J].

Dall'Asta, Chiara ;

Falavigna, Claudia ;

Galaverna, Gianni ;

Dossena, Arnaldo ;

Marchelli, Rosangela .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, 58 (22) :12042-12047

[8] Identification of microbial metabolites derived from in vitro fecal fermentation of different polyphenolic food sources [J].

Dall'Asta, Margherita ;

Calani, Luca ;

Tedeschi, Marianna ;

Jechiu, Lucia ;

Brighenti, Furio ;

Del Rio, Daniele .

NUTRITION, 2012, 28 (02) :197-203

[9] Digestibility and absorption of deoxynivalenol-3-β-glucoside in in vitro models [J].

De Nijs, M. ;

Van den Top, H. J. ;

Portier, L. ;

Oegema, G. ;

Kramer, E. ;

Van Egmond, H. P. ;

Hoogenboom, L. A. P. .

WORLD MYCOTOXIN JOURNAL, 2012, 5 (03) :319-324

[10] Lack of de-epoxidation of type B trichothecenes in incubates with human faeces [J].

Eriksen, GS ;

Pettersson, H .

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2003, 20 (06) :579-582