The Hemorrhagic Risk: How to Evaluate It

被引:4
作者
Di Fusco, Stefania Angela [1 ]
Colivicchi, Furio [1 ]
Santini, Massimo [1 ]
机构
[1] San Filippo Neri Hosp, Cardiovasc Dept, I-00135 Rome, Italy
来源
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY | 2013年 / 36卷 / 10期
关键词
bleeding risk; oral anticoagulation; atrial fibrillation; WARFARIN-ASSOCIATED HEMORRHAGE; ATRIAL-FIBRILLATION; BLEEDING RISK; INTRACRANIAL HEMORRHAGE; STROKE PREVENTION; EUROPEAN-SOCIETY; MANAGEMENT; ANTICOAGULATION; GUIDELINES; THERAPY;
D O I
10.1111/pace.12146
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This issue addresses the evaluation of hemorrhagic risk during antithrombotic treatment in atrial fibrillation patients. It illustrates the relevance of bleeding complications in the management of anticoagulation therapy and demonstrates the size of the problem among patients taking old and novel oral anticoagulant drugs. A survey of the main factors affecting the bleeding risk with pertinent supporting evidence is performed. Finally the paper discusses how to estimate the individual bleeding risk focusing on the HAS-BLED score, whose use is recommended by international guidelines.
引用
收藏
页码:1191 / 1197
页数:7
相关论文
共 33 条
[1]   Pharmacology and management of the vitamin K antagonists [J].
Ansell, Jack ;
Hirsh, Jack ;
Hylek, Elaine ;
Jacobson, Alan ;
Crowther, Mark ;
Palareti, Gualtiero .
CHEST, 2008, 133 (06) :160S-198S
[2]   Performance of the HEMORR2HAGES, ATRIA, and HAS-BLED Bleeding Risk-Prediction Scores in Patients With Atrial Fibrillation Undergoing Anticoagulation [J].
Apostolakis, Stavros ;
Lane, Deirdre A. ;
Guo, Yutao ;
Buller, Harry ;
Lip, Gregory Y. H. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 60 (09) :861-867
[3]   Genetic determinants of acenocoumarol and phenprocoumon maintenance dose requirements [J].
Cadamuro, Janne ;
Dieplinger, Benjamin ;
Felder, Thomas ;
Kedenko, Igor ;
Mueller, Thomas ;
Haltmayer, Meinhard ;
Patsch, Wolfgang ;
Oberkofler, Hannes .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2010, 66 (03) :253-260
[4]  
Camm AJ, 2012, EUROPACE, V14, P1385, DOI [10.1093/eurheartj/ehs253, 10.1093/europace/eus305]
[5]  
Camm AJ, 2010, EUROPACE, V12, P1360, DOI [10.1093/europace/euq350, 10.1093/eurheartj/ehq278]
[6]   Dabigatran versus Warfarin in Patients with Atrial Fibrillation. [J].
Connolly, Stuart J. ;
Ezekowitz, Michael D. ;
Yusuf, Salim ;
Eikelboom, John ;
Oldgren, Jonas ;
Parekh, Amit ;
Pogue, Janice ;
Reilly, Paul A. ;
Themeles, Ellison ;
Varrone, Jeanne ;
Wang, Susan ;
Alings, Marco ;
Xavier, Denis ;
Zhu, Jun ;
Diaz, Rafael ;
Lewis, Basil S. ;
Darius, Harald ;
Diener, Hans-Christoph ;
Joyner, Campbell D. ;
Wallentin, Lars .
NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (12) :1139-1151
[7]   Factors affecting bleeding risk during anticoagulant therapy in patients with atrial fibrillation: Observations from the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Study [J].
DiMarco, JP ;
Flaker, G ;
Waldo, AL ;
Corley, SD ;
Greene, HL ;
Safford, RE ;
Rosenfeld, LE ;
Mitrani, G ;
Nemeth, M .
AMERICAN HEART JOURNAL, 2005, 149 (04) :650-656
[8]   A New Risk Scheme to Predict Warfarin-Associated Hemorrhage The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study [J].
Fang, Margaret C. ;
Go, Alan S. ;
Chang, Yuchiao ;
Borowsky, Leila H. ;
Pomernacki, Niela K. ;
Udaltsova, Natalia ;
Singer, Daniel E. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 58 (04) :395-401
[9]   Advanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for atrial fibrillation [J].
Fang, MC ;
Chang, YC ;
Hylek, EM ;
Rosand, J ;
Greenberg, SM ;
Go, AS ;
Singer, DE .
ANNALS OF INTERNAL MEDICINE, 2004, 141 (10) :745-752
[10]   Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study [J].
Friberg, Leif ;
Rosenqvist, Marten ;
Lip, Gregory Y. H. .
EUROPEAN HEART JOURNAL, 2012, 33 (12) :1500-+