Risk of transferring malignant cells with transplanted frozen-thawed ovarian tissue

被引:273
作者
Dolmans, Marie-Madeleine [1 ]
Luyckx, Valerie [1 ]
Donnez, Jacques [2 ]
Andersen, Claus Yding [3 ]
Greve, Tine [3 ]
机构
[1] Catholic Univ Louvain, Pole Rech Gynecol, Inst Rech Expt & Clin, Clin Univ St Luc, B-1200 Brussels, Belgium
[2] Soc Rech Infertilite, Brussels, Belgium
[3] Rigshosp, Copenhagen Univ Hosp, Reprod Biol Lab, DK-2100 Copenhagen, Denmark
关键词
Ovarian tissue cryopreservation; ovarian tissue transplantation; cancer; risk; malignant cells; RESIDUAL DISEASE; HETEROTOPIC AUTOTRANSPLANTATION; FERTILITY PRESERVATION; CANCER-PATIENTS; LIVE BIRTH; PREGNANCY; CRYOPRESERVATION; LEUKEMIA; CONTAMINATION; CARCINOMA;
D O I
10.1016/j.fertnstert.2013.03.027
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Ovarian tissue cryopreservation and transplantation is a real option to preserve and restore fertility in young cancer patients. However, there is a concern regarding the possible presence of malignant cells in the ovarian tissue, which could lead to recurrence of the primary disease after reimplantation. A review of the existing literature was done to evaluate the risk of transplanting malignant cells in case of the main malignant indications for ovarian tissue cryopreservation. For ovarian tissue from patients with hematologic malignancies, it is of paramount importance to identify minimal residual disease before ovarian tissue transplantation. Indeed, these pathologies, reviewed here in detail, are considered to be most at risk of ovarian metastasis. ((c) 2013 by American Society for Reproductive Medicine.)
引用
收藏
页码:1514 / 1522
页数:9
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