Growth hormone therapy in short children born small for gestational age

被引:26
作者
de Zegher, F
Ong, KK
Ibáñez, L
Dunger, DB
机构
[1] Univ Leuven, Louvain, Belgium
[2] Univ Cambridge, Addenbrookes Hosp, Dept Paediat, Cambridge CB2 1TN, England
[3] MRC Epidemiol Unit, Strangeways Res Lab, Cambridge, England
[4] Univ Barcelona, Hosp St Joan Deu, Barcelona, Spain
关键词
growth hormone; insulin; insulin-like growth factor I; puberty; small for gestational age;
D O I
10.1159/000091520
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
There is still a lack of data from randomized, controlled, long-term studies of growth hormone (GH) treatment in children born small for gestational age (SGA), but the available evidence indicates consistently that GH therapy is a valid growth-promoting treatment in these children, particularly if started early. Whilst side effects appear uncommon, ongoing surveillance is required and treated children should be monitored for changes in glucose homeostasis, lipid profiles and blood pressure, especially during puberty. We provide an update on the safety and efficacy of GH treatment in short children born SGA.
引用
收藏
页码:145 / 152
页数:8
相关论文
共 47 条
[41]   Carbohydrate metabolism during long-term growth hormone treatment in children with short stature born small for gestational age [J].
Sas, T ;
Mulder, P ;
Aanstoot, HJ ;
Houdijk, M ;
Jansen, M ;
Reeser, M ;
Hokken-Koelega, A .
CLINICAL ENDOCRINOLOGY, 2001, 54 (02) :243-251
[42]   Body composition, blood pressure, and lipid metabolism before and during long-term growth hormone (CH) treatment in children with short stature born small for gestational age either with or without GH deficiency [J].
Sas, T ;
Mulder, P ;
Hokken-Koelega, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (10) :3786-3792
[43]   Serum lipid concentrations and growth characteristics in 12-year-old children born small for gestational age [J].
Tenhola, S ;
Martikainen, A ;
Rahiala, E ;
Herrgård, E ;
Halonen, P ;
Voutilainen, R .
PEDIATRIC RESEARCH, 2000, 48 (05) :623-628
[44]   Adult height after long-term, continuous growth hormone (GH) treatment in short children born small for gestational age: Results of a randomized, double-blind, dose-response GH trial [J].
van Pareren, Y ;
Mulder, P ;
Houdijk, M ;
Jansen, M ;
Reeser, M ;
Hokken-Koelega, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (08) :3584-3590
[45]  
VANPAREREN Y, 2001, PEDIAT RES S6, V49, pA74
[46]  
WILTON P, 1999, GROWTH HORMONE THERA, P349
[47]   The somatotropic axis in short children born small for gestational age: Relation to insulin resistance [J].
Woods, KA ;
Van Helvoirt, M ;
Ong, KKL ;
Mohn, A ;
Levy, J ;
De Zegher, F ;
Dunger, DB .
PEDIATRIC RESEARCH, 2002, 51 (01) :76-80