Functional balance between neuraminidase and haemagglutinin in influenza viruses

被引:108
作者
Gaymard, A. [1 ,2 ]
Le Briand, N. [1 ]
Frobert, E. [1 ,2 ]
Lina, B. [1 ,2 ]
Escuret, V. [1 ,2 ]
机构
[1] Univ Lyon 1, Univ Lyon, Fac Med Lyon Est, CIRI,INSERM,U1111,Equipe Virpath, Lyon, France
[2] Hosp Civils Lyon, Ctr Natl Reference Virus Influenzae France Sud, Lab Virol, Grp Hosp Nord, Lyon, France
关键词
Antiviral resistance; Haemagglutinin; Haemagglutinin/Neuraminidase balance; Host adaptation; Influenza viruses; Neuraminidase; MULTIBASIC CLEAVAGE SITE; RECEPTOR-BINDING; A VIRUS; SUBSTRATE-SPECIFICITY; N1; NEURAMINIDASE; ANTIGENIC CHANGE; H1N1; SUSCEPTIBILITY; GLYCOSYLATION; MUTATIONS;
D O I
10.1016/j.cmi.2016.07.007
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Seasonal influenza A and B viruses are important human pathogens responsible for significant morbidity and mortality worldwide. In addition, influenza A zoonotic viruses are a constant pandemic threat. These viruses present two major surface glycoproteins: the haemagglutinin (HA) and the neuraminidase (NA). These two glycoproteins both recognize the sialic acid and have complementary activities, the HA binds the sialic acid through its receptor-binding site, the NA is a receptor-destroying enzyme that cleaves alpha 2-3 and alpha 2-6-linked sialic acids. Therefore, the functional HA/NA balance is a critical factor for a good viral fitness and plays a major role in overcoming the host barrier and the efficiency of sustained human-to-human transmission. Although the two glycoproteins are in constant evolution, the HA/NA balance seems to remain stable in human viruses because an optimal balance is required to maintain good viral fitness. Understanding the evolution of influenza viruses requires an in-depth exploration of the HA/NA balance. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:975 / 983
页数:9
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