The Therapeutic Effect of Tigecycline, Unlike That of Ceftazidime, Is Not Influenced by whether the Klebsiella pneumoniae Strain Produces Extended-Spectrum β-Lactamases in Experimental Pneumonia in Rats

被引：10
作者：
Goessens, Wil H. F. [1 ]
Mouton, Johan W. [2 ]
ten Kate, Marian T. [1 ]
Soergel, Fritz [3 ,4 ,5 ]
Kinzig, Martina [3 ]
Bakker-Woudenberg, Irma A. J. M. [1 ]
机构：
[1] Erasmus Univ, Med Ctr, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6525 ED Nijmegen, Netherlands
[3] Inst Biomed & Pharmaceut Res, Nurnberg, Germany
[4] Univ Duisburg Essen, Dept Pharmacol, Duisburg, Germany
[5] Univ Duisburg Essen, Dept Pharmacol, Essen, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 01期
关键词：
INFECTIONS; RESISTANCE; MECHANISMS; EFFICACY;
D O I：
10.1128/AAC.01154-12
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The efficacies of tigecycline and ceftazidime against fatal pneumonia in rats caused by an extended-spectrum beta-lactamase (ESBL)-positive Klebsiella pneumoniae strain or its wild-type (WT) progenitor were compared. Ceftazidime at 12.5 or 50 mg/kg of body weight twice daily (b.i.d.) was effective (50% or 100% rat survival) in pneumonia caused by the WT isolate but unsuccessful (100% rat mortality) in pneumonia caused by the ESBL-positive variant. In contrast, tigecycline at 6.25, 12.5, or 25 mg/kg b.i.d. showed dosage-dependent efficacy up to 100% rat survival irrespective of the ESBL character of the infecting organism.
引用
收藏
页码：643 / 646
页数：4
相关论文
共 16 条
  • [1] Effect of treatment duration on pharmacokinetic/pharmacodynamic indices correlating with therapeutic efficacy of ceftazidime in experimental Klebsiella pneumoniae lung infection
    Bakker-Woudenberg, Irma A. J. M.
    ten Kate, Marian T.
    Goessens, Wil H. F.
    Mouton, Johan W.
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (09) : 2919 - 2925
  • [2] THERAPEUTIC ACTIVITIES OF CEFAZOLIN, CEFOTAXIME, AND CEFTAZIDIME AGAINST EXPERIMENTALLY INDUCED KLEBSIELLA-PNEUMONIAE PNEUMONIA IN RATS
    BAKKERWOUDENBERG, IAJM
    VANDENBERG, JC
    MICHEL, MF
    [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1982, 22 (06) : 1042 - 1050
  • [3] Salvage therapy with tigecycline for recurrent infection caused by ertapenem-resistant extended-spectrum β-lactamase-producing Klebsiella pneumoniae
    Chen, Po-Lin
    Yan, Jing-Jou
    Wu, Chi-Jung
    Lee, Hsin-Chun
    Chang, Chia-Ming
    Lee, Nan-Yao
    Ko, Nai-Ying
    Wang, Li-Rong
    Shih, Hsin-I
    Lee, Ching-Chi
    Ko, Wen-Chien
    [J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2010, 68 (03) : 312 - 314
  • [4] Effect of the anticoagulant ethylenediamine tetra-acetic acid (EDTA) on the estimation of pharmacokinetic parameters: A case study with tigecycline and ciprofloxacin
    Chen, Q.
    Tung, E. C.
    Ciccotto, S. L.
    Strauss, J. R.
    Ortiga, R.
    Ramsay, K. A.
    Tang, W.
    [J]. XENOBIOTICA, 2008, 38 (01) : 76 - 86
  • [5] Council of the European Union, 1986, GUID PROT EXP AN
  • [6] Comparison of tigecycline with imipenem/cilastatin for the treatment of hospital-acquired pneumonia
    Freire, Antonio T.
    Melnyk, Vasyl
    Kim, Min Ja
    Datsenko, Oleksiy
    Dzyublik, Oleksandr
    Glumcher, Felix
    Chuang, Yin-Ching
    Maroko, Robert T.
    Dukart, Gary
    Cooper, C. Angel
    Korth-Bradley, Joan M.
    Dartois, Nathalie
    Gandjini, Hassan
    [J]. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2010, 68 (02) : 140 - 151
  • [7] Other antimicrobials of interest in the era of extended-spectrum β-lactamases:: fosfomycin, nitrofurantoin and tigecycline
    Garau, J.
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2008, 14 : 198 - 202
  • [8] Patterns of resistance associated with integrons, the extended-spectrum β-lactamase SHV-5 gene, and a multidrug efflux pump of Klebsiella pneumoniae causing a nosocomial outbreak
    Gruteke, P
    Goessens, W
    van Gils, J
    Peerbooms, P
    Lemmens-den Toom, N
    van Santen-Verheuvel, M
    van Belkum, A
    Verbrugh, H
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (03) : 1161 - 1166
  • [9] Mechanisms of disease:: The new β-lactamases
    Jacoby, GA
    Munoz-Price, LS
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 352 (04) : 380 - 391
  • [10] The pharmacokinetic and pharmacodynamic profile of tigecycline
    Meagher, AK
    Ambrose, PG
    Grasela, TH
    Ellis-Grosse, EJ
    [J]. CLINICAL INFECTIOUS DISEASES, 2005, 41 : S333 - S340
12