Impact of Dysfunctional Adipose Tissue Depots on the Cardiovascular System

被引：11

作者：

D'Oria, Rossella ^{[1
]}

Genchi, Valentina Annamaria ^{[1
]}

Caccioppoli, Cristina ^{[1
]}

Calderoni, Isabella ^{[1
]}

Marrano, Nicola ^{[1
]}

Biondi, Giuseppina ^{[1
]}

Borrelli, Anna ^{[1
]}

Di Gioia, Ludovico ^{[1
]}

Giorgino, Francesco ^{[1
]}

Laviola, Luigi ^{[1
]}

机构：

[1] Univ Bari Aldo Moro, Dept Precis & Regenerat Med & Ionian Area, Sect Internal Med Endocrinol Androl & Metab Dis, I-70124 Bari, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 22期

关键词：

obesity; cardiovascular risk; epicardial adipose tissue; lifestyle modification; GLP-1R agonists; SGLT2; inhibitors; bariatric surgery; MESENTERIC FAT THICKNESS; GLP-1 RECEPTOR AGONISTS; GLUCAGON-LIKE PEPTIDE-1; BODY-MASS INDEX; EPICARDIAL FAT; HEART-FAILURE; TNF-ALPHA; DIABETES-MELLITUS; SKELETAL-MUSCLE; WEIGHT-LOSS;

D O I：

10.3390/ijms232214296

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity with its associated complications represents a social, economic and health problem of utmost importance worldwide. Specifically, obese patients carry a significantly higher risk of developing cardiovascular disease compared to nonobese individuals. Multiple molecular mechanisms contribute to the impaired biological activity of the distinct adipose tissue depots in obesity, including secretion of proinflammatory mediators and reactive oxygen species, ultimately leading to an unfavorable impact on the cardiovascular system. This review summarizes data relating to the contribution of the main adipose tissue depots, including both remote (i.e., intra-abdominal, hepatic, skeletal, pancreatic, renal, and mesenteric adipose fat), and cardiac (i.e., the epicardial fat) adipose locations, on the cardiovascular system. Finally, we discuss both pharmacological and non-pharmacological strategies aimed at reducing cardiovascular risk through acting on adipose tissues, with particular attention to the epicardial fat.

引用

页数：20

共 165 条

[131] Proteomic analysis of epicardial and subcutaneous adipose tissue reveals differences in proteins involved in oxidative stress [J].