Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

被引:26
|
作者
Kuo, Ting-Yun [1 ]
Jhang, Cuei-Fang [1 ]
Lin, Che-Min [1 ]
Hsien, Tzu-Yang [2 ]
Hsieh, Hsyue-Jen [1 ]
机构
[1] Natl Taiwan Univ, Dept Chem Engn, Taipei 106, Taiwan
[2] China Univ Technol, Gen Educ Ctr, Taipei 116, Taiwan
来源
OPEN PHYSICS | 2017年 / 15卷 / 01期
关键词
electrospinning; core/shell structures; gum arabic; drug release; Korsmeyer-Peppas model; CORE-SHELL NANOFIBERS; CHITOSAN NANOFIBERS; POLYMER NANOFIBERS; CONTROLLED-RELEASE; FIBERS; DEGRADATION;
D O I
10.1515/phys-2017-0125
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
It is difficult to fabricate chitosan-wrapped coaxial nanofibers, because highly viscous chitosan solutions might hinder the manufacturing process. To overcome this difficulty, our newly developed method, which included the addition of a small amount of gum arabic, was utilized to prepare much less viscous chitosan solutions. In this way, coaxial polyvinyl alcohol (PVA)/chitosan (as core/shell) nanofiber membranes were fabricated successfully by coaxial electrospinning. The core/shell structures were confirmed by TEM, and the existence of PVA and chitosan was also verified using FT-IR and TGA. The tensile strength of the nanofiber membranes was increased from 0.6-0.7 MPa to 0.8-0.9 MPa after being crosslinked with glutaraldehyde. The application potential of the PVA/chitosan nanofiber membranes was tested in drug release experiments by loading the core (PVA) with theophylline as a model drug. The use of the coaxial PVA/chitosan nanofiber membranes in drug release extended the release time of theophylline from 5 minutes to 24 hours. Further, the release mechanisms could be described by the Korsmeyer-Peppas model. In summary, by combining the advantages of PVA and chitosan (good mechanical strength and good biocompatibility respectively), the coaxial PVA/chitosan nanofiber membranes are potential biomaterials for various biomedical applications.
引用
收藏
页码:1004 / 1014
页数:11
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