Myotoxic activity of a Gln-49 phospholipase A2 from Agkistrodon blomhoffii ussurensis snake venom

被引：0
作者：
Bao, YM [1 ]
Bu, PC
Yang, J
Yang, W
Jia, PL
An, LJ
机构：
[1] Dalian Univ Technol, Dept Biosci & Biotechnol, Dalian 116024, Peoples R China
[2] Chinese Acad Sci, Inst Biophys, Beijing 100101, Peoples R China
[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
来源：
PROGRESS IN NATURAL SCIENCE | 2006年 / 16卷 / 02期
关键词：
snake venom; phospholipase A(2); Agkistrodon blomhoffii ussurensis; myotoxic activity;
D O I：
暂无
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
A novel myotoxic protein phospholipase A(2)(PLA(2)), denoted as Gln49-PLA(2), has been isolated from snake venom of Agkistrodon blomhoffii ussurensis, which has weak lethal effect and apparent anticoagulant activity, but lacks the PLA(2) and hemorrhagenic activity. Gln49-PLA(2) obviously increases of plasma creatine-kinase (GK) upon intramuscular injection in mice, suggesting that it may induce a dose-dependent myonecrosis. Histological studies also reveal morphological changes in mouse skeletal muscles, including extensive myonecrosis, hemorrhage and neutrophil infiltration in the treated animals. The myotoxic ability induced by Gln49-PLA(2) can be partially inhibited by heparin.
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页码：178 / 182
页数：5
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