Brain metastases from breast cancer: prognostic factors and tailored management

被引：2

作者：

Tallet, Agnes ^{[1
]}

Kirova, Youlia ^{[2
]}

机构：

[1] Inst J Paoli I Calmettes, Dept Oncol Radiotherapie, F-13273 Marseille 09, France

[2] Inst Curie, Dept Oncol Radiotherapie, F-75248 Paris 05, France

来源：

BULLETIN DU CANCER | 2013年 / 100卷 / 01期

关键词：

breast cancer; brain metastases; multidisciplinary treatment; RADIATION-THERAPY; STEREOTACTIC RADIOSURGERY; PHASE-III; POSTOPERATIVE RADIOTHERAPY; CEREBRAL METASTASES; SURGICAL RESECTION; SINGLE METASTASES; RANDOMIZED-TRIAL; SURVIVAL; CONCURRENT;

D O I：

10.1684/bdc.2012.1613

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

During the last decades, advances in diagnostic and therapeutic technologies have modified the management of brain metastases, which is currently tailored to the type of primary site and to prognostic factors isolated in multivariate analyses. The aim of this article is to take stock of the current state of knowledge regarding prognostic factors in the setting of brain metastases from breast cancer as well as prognostic classifications proposed in this context. An appropriate multidisciplinary treatment for each prognostic class will be then discussed in light of the results of major randomized controlled trials enrolling patients with brain metastases from breast cancer.

引用

页码：63 / 67

页数：5

共 35 条

[1] Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial [J].

Andrews, DW ;

Scott, CB ;

Sperduto, PW ;

Flanders, AE ;

Gaspar, LE ;

Schell, MC ;

Werner-Wasik, M ;

Demas, W ;

Ryu, J ;

Bahary, JP ;

Souhami, L ;

Rotman, M ;

Mehta, MP ;

Curran, WJ .

LANCET, 2004, 363 (9422) :1665-1672

[2] Phase II Randomized trial of temozolomide and concurrent radiotherapy in patients with brain metastases [J].

Antonadou, D ;

Paraskevaidis, M ;

Sarris, G ;

Coliarakis, N ;

Economou, I ;

Karageorgis, P ;

Throuvalas, N .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (17) :3644-3650

[3] Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone [J].

Aoyama, Hidefumi ;

Tago, Masao ;

Kato, Norio ;

Toyoda, Tatsuya ;

Kenjyo, Masahiro ;

Hirota, Saeko ;

Shioura, Hiroki ;

Inomata, Taisuke ;

Kunieda, Etsuo ;

Hayakawa, Kazushige ;

Nakagawa, Keiichi ;

Kobashi, Gen ;

Shirato, Hiroki .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 68 (05) :1388-1395

[4] Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases - A randomized controlled trial [J].

Aoyama, Hidefumi ;

Shirato, Hiroki ;

Tago, Masao ;

Nakagawa, Keiichi ;

Toyoda, Tatsuya ;

Hatano, Kazuo ;

Kenjyo, Masahiro ;

Oya, Natsuo ;

Hirota, Saeko ;

Shioura, Hiroki ;

Kunieda, Etsuo ;

Inomata, Taisuke ;

Hayakawa, Kazushige ;

Katoh, Norio ;

Kobashi, Gen .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (21) :2483-2491

[5]

Bachelot T, 2011, J CLIN ONCOL, V29, P509

[6] Lymphopenia: A new independent prognostic factor for survival in patients treated with whole brain radiotherapy for brain metastases from breast carcinoma [J].

Claude, L ;

Perol, D ;

Ray-Coquard, I ;

Petit, T ;

Blay, JY ;

Carrie, C ;

Bachelot, T .

RADIOTHERAPY AND ONCOLOGY, 2005, 76 (03) :334-339

[7] Incidence of cerebral metastases in patients treated with trastuzumab for metastatic breast cancer [J].

Clayton, AJ ;

Danson, S ;

Jolly, S ;

Ryder, WDJ ;

Burt, PA ;

Stewart, AL ;

Wilkinson, PM ;

Welch, RS ;

Magee, B ;

Wilson, G ;

Howell, A ;

Wardley, AM .

BRITISH JOURNAL OF CANCER, 2004, 91 (04) :639-643

[8] THE ROLE OF POSTOPERATIVE RADIOTHERAPY AFTER RESECTION OF SINGLE BRAIN METASTASES [J].

DEANGELIS, LM ;

MANDELL, LR ;

THALER, HT ;

KIMMEL, DW ;

GALICICH, JH ;

FUKS, Z ;

POSNER, JB .

NEUROSURGERY, 1989, 24 (06) :798-805

[9] Survival in patients with brain metastases from breast cancer [J].

Eichler, April F. ;

Kuter, Irene ;

Ryan, Paula ;

Schapira, Lidia ;

Younger, Jerry ;

Henson, John W. .

CANCER, 2008, 112 (11) :2359-2367

[10] Treatment of Brain Metastases: Chemotherapy [J].

Grimm, Sean A. .

CURRENT ONCOLOGY REPORTS, 2012, 14 (01) :85-90

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