Methylated DNA and microRNA in Body Fluids as Biomarkers for Cancer Detection

被引：29
作者：
Ma, Yanning [1 ]
Wang, Xian [1 ]
Jin, Hongchuan [1 ]
机构：
[1] Zhejiang Univ, Sir Runrun Shaw Hosp, Inst Clin Sci, Lab Canc Biol,Dept Med Oncol,Med Sch, Hangzhou 310029, Zhejiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2013年 / 14卷 / 05期
关键词：
cancer; biomarker; DNA methylation; miRNAs; CPG ISLAND HYPERMETHYLATION; CIRCULATING TUMOR-CELLS; MINIMALLY INVASIVE BIOMARKERS; EPIGENETIC MARKER PANEL; BLOOD-BASED MARKERS; PROMOTER HYPERMETHYLATION; LUNG-CANCER; PROSTATE-CANCER; PLASMA DNA; BREAST-CANCER;
D O I：
10.3390/ijms140510307
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Epigenetic alterations including DNA methylation and microRNAs (miRNAs) play important roles in the initiation and progression of human cancers. As the extensively studied epigenetic changes in tumors, DNA methylation and miRNAs are the most potential epigenetic biomarkers for cancer diagnosis. After the identification of circulating cell-free nuclear acids, increasing evidence demonstrated great potential of cell-free epigenetic biomarkers in the blood or other body fluids for cancer detection.
引用
收藏
页码：10307 / 10331
页数：25
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