Zebrafish genetic map with 2000 microsatellite markers

被引：285

作者：

Shimoda, N

Knapik, EW

Ziniti, J

Sim, C

Yamada, E

Kaplan, S

Jackson, D

de Sauvage, F

Jacob, H

Fishman, MC

机构：

[1] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Charlestown, MA 02129 USA

[2] Harvard Univ, Sch Med, Charlestown, MA 02129 USA

[3] GSF, Natl Res Ctr Environm & Hlth, Inst Mammalian Genet, D-85758 Neuherberg, Germany

[4] Genentech Inc, Dept Mol Oncol, S San Francisco, CA 94080 USA

[5] Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA

来源：

GENOMICS | 1999年 / 58卷 / 03期

关键词：

zebrafish; linkage map; microsatellite repeat; polymorphism; microsatellite expansion;

D O I：

10.1006/geno.1999.5824

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The zebrafish is the first vertebrate organism used for large-scale genetic screens seeking genes critical to development, These screens have been quite successful, with more than 1800 recessive mutations discovered that speak to morphogenesis of the vertebrate embryo. The cloning of the mutant genes depends on a dense genetic map. The 2000 markers we present here, using microsatellite (CA) repeats, provides 1,2-cM average resolution. One centimorgan in zebrafish is about 0.74 megabase, so, for many mutations, these markers are close enough to begin positional cloning by YAC walks. (C) 1999 Academic Press.

引用

页码：219 / 232

页数：14

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