Single nucleotide polymorphisms rs2120131, rs4935047, and rs7095891 in the MBL2 gene show no association with susceptibility to chronic hepatitis B in a Chinese Han population

被引：3

作者：

Zhang, Tian-Chen ^{[1
,2
]}

Liu, Wei ^{[1
]}

Liu, Xiao-Qing ^{[1
]}

Pan, Fa-Ming ^{[2
]}

Gao, Yu-Feng ^{[3
]}

Yan, Fang ^{[3
]}

Li, Xu ^{[3
]}

机构：

[1] Jiangxi Ctr Dis Control & Prevent, Nanchang 330000, Jiangxi, Peoples R China

[2] Anhui Med Univ Anhui, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei 230032, Anhui, Peoples R China

[3] Anhui Med Univ, Affiliated Hosp 2, Dept Infect Dis, Hefei 230032, Anhui, Peoples R China

来源：

JOURNAL OF MEDICAL VIROLOGY | 2013年 / 85卷 / 04期

关键词：

hepatitis B virus; MBL2; gene; polymorphism; MANNOSE-BINDING LECTIN; VIRUS INFECTION; PROMOTER POLYMORPHISMS; VIRAL-HEPATITIS; INNATE IMMUNITY; DISEASE; PROGRESSION; CLEARANCE; ALLELES;

D O I：

10.1002/jmv.23514

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Thus far, many studies have evaluated the correlation between MBL2 gene polymorphisms and hepatitis B infection. Tag single nucleotide polymorphisms (SNPs) were used to investigate the relationship between MBL2 gene polymorphisms and susceptibility to chronic hepatitis B virus (HBV) infection by comparing 996 chronic HBV infection cases to 301 acute infection controls. There was no significant correlation between rs2120131, rs4935047, and rs7095891 and chronic HBV infection. This suggested that the new SNPs within MBL2 were not associated with susceptibility to chronic hepatitis B in a Chinese Han population. J. Med. Virol. 85:602607, 2013. (c) 2013 Wiley Periodicals, Inc.

引用

页码：602 / 607

页数：6

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