TAK1 mediates convergence of cellular signals for death and survival

被引：70

作者：

Aashaq, Sabreena ^{[1
]}

Batool, Asiya ^{[1
]}

Andrabi, Khurshid I. ^{[1
]}

机构：

[1] Univ Kashmir, Dept Biotechnol, Srinagar 190006, Jammu & Kashmir, India

来源：

APOPTOSIS | 2019年 / 24卷 / 1-2期

关键词：

Apoptosis; Autophagy; Cytokine; Inflammatory; Smad; ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; P70; S6; KINASE; FATTY-ACID OXIDATION; MAMMALIAN TARGET; MAP KINASE; YEAST SNF1; DEPENDENT ACTIVATION; STRUCTURAL BASIS; BINDING PARTNER;

D O I：

10.1007/s10495-018-1490-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TGF- activated kinase 1, a MAPK kinase kinase family serine threonine kinase has been implicated in regulating diverse range of cellular processes that include embryonic development, differentiation, autophagy, apoptosis and cell survival. TAK1 along with its binding partners TAB1, TAB2 and TAB3 displays a complex pattern of regulation that includes serious crosstalk with major signaling pathways including the C-Jun N-terminal kinase (JNK), p38 MAPK, and I-kappa B kinase complex (IKK) involved in establishing cellular commitments for death and survival. This review also highlights how TAK1 orchestrates regulation of energy homeostasis via AMPK and its emerging role in influencing mTORC1 pathway to regulate death or survival in tandem.

引用

页码：3 / 20

页数：18

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