TAK1 mediates convergence of cellular signals for death and survival

被引：70

作者：

Aashaq, Sabreena ^{[1
]}

Batool, Asiya ^{[1
]}

Andrabi, Khurshid I. ^{[1
]}

机构：

[1] Univ Kashmir, Dept Biotechnol, Srinagar 190006, Jammu & Kashmir, India

来源：

APOPTOSIS | 2019年 / 24卷 / 1-2期

关键词：

Apoptosis; Autophagy; Cytokine; Inflammatory; Smad; ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; P70; S6; KINASE; FATTY-ACID OXIDATION; MAMMALIAN TARGET; MAP KINASE; YEAST SNF1; DEPENDENT ACTIVATION; STRUCTURAL BASIS; BINDING PARTNER;

D O I：

10.1007/s10495-018-1490-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TGF- activated kinase 1, a MAPK kinase kinase family serine threonine kinase has been implicated in regulating diverse range of cellular processes that include embryonic development, differentiation, autophagy, apoptosis and cell survival. TAK1 along with its binding partners TAB1, TAB2 and TAB3 displays a complex pattern of regulation that includes serious crosstalk with major signaling pathways including the C-Jun N-terminal kinase (JNK), p38 MAPK, and I-kappa B kinase complex (IKK) involved in establishing cellular commitments for death and survival. This review also highlights how TAK1 orchestrates regulation of energy homeostasis via AMPK and its emerging role in influencing mTORC1 pathway to regulate death or survival in tandem.

引用

页码：3 / 20

页数：18

共 197 条

[1] Evidence for a role of MSK1 in transforming growth factor-β-mediated responses through p38α and Smad signaling pathways [J].

Abécassis, L ;

Rogier, E ;

Vazquez, A ;

Atfi, A ;

Bourgeade, MF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (29) :30474-30479

[2] The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation [J].

Ahmed, Neesar ;

Zeng, Minghui ;

Sinha, Indrajit ;

Polin, Lisa ;

Wei, Wei-Zen ;

Rathinam, Chozhavendan ;

Flavell, Richard ;

Massoumi, Ramin ;

Venuprasad, K. .

NATURE IMMUNOLOGY, 2011, 12 (12) :1176-U1

[3] Toll-like receptor signaling [J].

Akira, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (40) :38105-38108

[4] New Insights into mTOR Signaling: mTORC2 and Beyond [J].

Alessi, Dario R. ;

Pearce, Laura R. ;

Garcia-Martinez, Juan M. .

SCIENCE SIGNALING, 2009, 2 (67) :pe27

[5] Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site [J].

Ali, SM ;

Sabatini, DM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (20) :19445-19448

[6] AMP-activated protein kinase plays a role in the control of food intake [J].

Andersson, U ;

Filipsson, K ;

Abbott, CR ;

Woods, A ;

Smith, K ;

Bloom, SR ;

Carling, D ;

Small, CJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (13) :12005-12008

[7] The balance between IL-1 and IL-1Ra in disease [J].

Arend, WR .

CYTOKINE & GROWTH FACTOR REVIEWS, 2002, 13 (4-5) :323-340

[8] Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy [J].

Armour, Sean M. ;

Baur, Joseph A. ;

Hsieh, Sherry N. ;

Land-Bracha, Abigail ;

Thomas, Sheila M. ;

Sinclair, David A. .

AGING-US, 2009, 1 (06) :515-528

[9] The Prevalence of TNFα-Induced Necrosis over Apoptosis Is Determined by TAK1-RIP1 Interplay [J].

Arslan, Seda Coel ;

Scheidereit, Claus .

PLOS ONE, 2011, 6 (10)

[10] Regulated Cell Death: Signaling and Mechanisms [J].

Ashkenazi, Avi ;

Salvesen, Guy .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30, 2014, 30 :337-356

← 1 2 3 4 5 6 7 8 9 10 →