Development of anticancer agents targeting the Wnt/β-catenin signaling

被引：1

作者：

Zhang, Xiangqian ^{[1
]}

Hao, Jijun ^{[2
,3
]}

机构：

[1] Yanan Univ, Coll Life Sci, Yanan 716000, Shaanxi, Peoples R China

[2] Western Univ Hlth Sci, Coll Vet Med, Pomona, CA 91766 USA

[3] Western Univ Hlth Sci, Grad Coll Biomed Sci, Pomona, CA 91766 USA

来源：

AMERICAN JOURNAL OF CANCER RESEARCH | 2015年 / 5卷 / 08期

关键词：

Wnt/beta-catenin signaling; beta-catenin; cancer; small molecules; biologic agents; therapeutic; safety and clinic; SMALL-MOLECULE INHIBITOR; SEGMENT POLARITY GENE; BETA-CATENIN; WNT PATHWAY; STEM-CELLS; SMALL-INTESTINE; PDZ DOMAIN; FRIZZLED RECEPTORS; COLORECTAL-CANCER; PROTEIN;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Wnt/beta-catenin signaling plays indispensable roles in both embryonic development and adult homeostasis. Abnormal regulation of this pathway is implicated in many types of cancer. Consequently, substantial efforts have made to develop therapeutic agents as anticancer drugs by specifically targeting the Wnt/beta-catenin pathway. Here we systematically review the potential therapeutic agents that have been developed to date for inhibition of the Wnt/beta-catenin cascade as well as current status of clinical trials of some of these agents.

引用

页码：2344 / 2360

页数：17

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