Occurrence of deoxynivalenol in cereals and exposure risk assessment in Indian population

被引：64

作者：

Mishra, Sakshi ^{[1
,2
]}

Ansari, Kausar M. ^{[1
]}

Dwivedi, Premendra D. ^{[1
]}

Pandey, Haushila P. ^{[2
]}

Das, Mukul ^{[1
]}

机构：

[1] IITR, CSIR, Lucknow 226001, Uttar Pradesh, India

[2] Banaras Hindu Univ, Dept Biochem, Varanasi 221005, Uttar Pradesh, India

来源：

FOOD CONTROL | 2013年 / 30卷 / 02期

关键词：

Deoxynivalenol; High performance liquid chromatography (HPLC); High pressure thin liquid chromatography (HPTLC); LC-MS; Wheat; Maize; Barley; ACTIVATED PROTEIN-KINASE; FUSARIUM MYCOTOXINS; WHEAT; NIVALENOL; TRICHOTHECENES; ZEARALENONE; EXPRESSION; PRODUCTS; BARLEY; RICE;

D O I：

10.1016/j.foodcont.2012.07.041

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Deoxynivalenol (DON) is a toxic fungal metabolite that frequently contaminates cereal crops. The occurrence of DON in hundred samples of wheat, maize and barley collected from different districts of Uttar Pradesh, India was examined. DON was detected in 30% samples out of which 7% samples exceeded the FSSR (Food Safety and Standard Regulation, India) limit (1 mg/kg). The contamination levels ranged from 0.01 mg/kg to 4.73 mg/kg. Of all the hundred cereal samples analyzed by HPLC, 19 positive samples (within the LOQ of 0.043 mg/kg) were further quantified by HPTLC, which showed comparable results suggesting that HPTLC is an equally reliable and cost effective method. Validation of DON in samples was performed by LC-MS analysis. Based on results of monitoring and the average actual consumption of wheat in India, the 90th percentile value of estimated daily intake (EDI) of DON was found to be 7.72 mu g DON/kg body weight which exceeded the Provisional Maximum Tolerable Daily Intake (PMTDI 1 mu g DON/kg-bw) proposed by JECFA by 7.7 folds there by suggesting the possibility of DON exposure to humans. Since DON levels have been set for wheat only there is a need to formulate regulatory standards for other cereals so as to reduce the exposure risk to DON. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：549 / 555

页数：7

共 42 条

[41] Ribotoxic mycotoxin deoxynivalenol induces G2/M cell cycle arrest via P21Cip/WAF1 mRNA stabilization in human epithelial cells [J].