Inhibition of preadipocyte differentiation by germacranolides from Calea urticifolia in 3T3-L1 cells

被引：17
|
作者：
Matsuura, N
Yamada, M
Suzuki, H
Hasegawa, N
Kurosaka, C
Ubukata, M
Tanaka, T
Iinuma, M
机构：
[1] Okayama Univ Sci, Dept Life Sci, Fac Sci, Okayama 7000005, Japan
[2] Meiji Dairies Corp, Koto Ku, Tokyo 1368908, Japan
[3] Toyama Prefectural Univ, Biotechnol Res Ctr, Toyama 9390398, Japan
[4] Hokkaido Univ, Grad Sch Agr, Kita Ku, Sapporo, Hokkaido 0608589, Japan
[5] Gifu Prefectural Inst Hlth & Environm Sci, Gifu 5040838, Japan
[6] Gifu Pharmaceut Univ, Gifu 5028585, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2005年 / 69卷 / 12期
关键词：
germacranolide; 3T3-L1; differentiation; inhibitor; Calea urticifolia;
D O I：
10.1271/bbb.69.2470
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of germacranolides isolated from Calea urticifolia on adipocytic differentiation of 3T3-L1 cells were examined. These germacranolides inhibited adipogenesis at a concentration of 1.25-5 mu m. But no inhibitory activity against cell proliferation and no nonspecific binding activity to protein were observed. These results indicate that these germacranolides are the specific inhibitors of preadipocyte differentiation.
引用
收藏
页码：2470 / 2474
页数：5
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