Auto-masked 2D/3D image registration and its validation with clinical cone-beam computed tomography

被引:15
作者
Steininger, P. [1 ]
Neuner, M. [1 ]
Weichenberger, H. [1 ,2 ]
Sharp, G. C. [3 ]
Winey, B. [3 ]
Kametriser, G. [2 ]
Sedlmayer, F. [1 ,2 ]
Deutschmann, H. [1 ,2 ]
机构
[1] Paracelsus Med Univ, Inst Res & Dev Adv Radiat Technol radART, A-5020 Salzburg, Austria
[2] Paracelsus Med Univ, Univ Clin Radiotherapy & Radiooncol, A-5020 Salzburg, Austria
[3] Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02114 USA
关键词
GUIDED RADIATION-THERAPY; 2D-3D REGISTRATION; DIGITAL TOMOSYNTHESIS; CT; RADIOTHERAPY; RECONSTRUCTION; IMPLEMENTATION; GUIDANCE; SYSTEMS;
D O I
10.1088/0031-9155/57/13/4277
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Image-guided alignment procedures in radiotherapy aim at minimizing discrepancies between the planned and the real patient setup. For that purpose, we developed a 2D/3D approach which rigidly registers a computed tomography (CT) with two x-rays by maximizing the agreement in pixel intensity between the x-rays and the corresponding reconstructed radiographs from the CT. Moreover, the algorithm selects regions of interest (masks) in the x-rays based on 3D segmentations from the pre-planning stage. For validation, orthogonal x-ray pairs from different viewing directions of 80 pelvic cone-beam CT (CBCT) raw data sets were used. The 2D/3D results were compared to corresponding standard 3D/3D CBCT-to-CT alignments. Outcome over 8400 2D/3D experiments showed that parametric errors in root mean square were <0.18 degrees (rotations) and <0.73 mm (translations), respectively, using rank correlation as intensity metric. This corresponds to a mean target registration error, related to the voxels of the lesser pelvis, of <2mm in 94.1% of the cases. From the results we conclude that 2D/3D registration based on sequentially acquired orthogonal x-rays of the pelvis is a viable alternative to CBCT-based approaches if rigid alignment on bony anatomy is sufficient, no volumetric intra-interventional data set is required and the expected error range fits the individual treatment prescription.
引用
收藏
页码:4277 / 4292
页数:16
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