Menadione inhibits MIBG uptake in two neuroendocrine cell lines

被引：3

作者：

Cornelissen, J

Tytgat, GAM

vandenBrug, M

vanKuilenburg, ABP

Voute, PA

vanGennip, AH

机构：

[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT PEDIAT,NL-1100 DE AMSTERDAM,NETHERLANDS

[2] UNIV AMSTERDAM,ACAD MED CTR,DEPT CLIN CHEM,NL-1100 DE AMSTERDAM,NETHERLANDS

[3] UNIV AMSTERDAM,ACAD MED CTR,DEPT RADIOBIOL,NL-1100 DE AMSTERDAM,NETHERLANDS

来源：

JOURNAL OF NEURO-ONCOLOGY | 1997年 / 31卷 / 1-2期

关键词：

meta-iodobenzylguanidine; menadione; oxidative stress; neuroblastoma; uptake;

D O I：

10.1023/A:1005718421774

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this paper we report on our studies of the effect of menadione on the uptake of MIBG in the neuroendocrine cell lines PC12 and SK-N-SH. Menadione inhibits the uptake of MIBG in both cell lines in a dose-dependent manner. Inhibition of MIBG uptake is most pronounced in the PC12 cell line. Comparison of the inhibitory action of menadione on the uptake and retention of MIBG with that of imipramine and reserpine suggests that menadione inhibits uptake 1 mediated uptake as well as granular storage.

引用

页码：147 / 151

页数：5

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