Plasma Exchange for Urgent Apixaban Reversal in a Case of Hemorrhagic Tamponade after Pacemaker Implantation

被引：10

作者：

Lam, Wilson W. ^{[1
,2
]}

Reyes, Meredith A. ^{[3
,4
]}

Seger, John J. ^{[1
,2
]}

机构：

[1] Texas Heart Inst, Dept Cardiol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Internal Med, Cardiol Sect, Houston, TX 77030 USA

[3] CHI St Lukes Hlth Baylor St Lukes Med Ctr, Dept Pathol, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA

来源：

TEXAS HEART INSTITUTE JOURNAL | 2015年 / 42卷 / 04期

关键词：

Anticoagulants/administration & dosage/adverse effects/antagonists & inhibitors/therapeutic use; apixaban; atrial fibrillation/complications/drug therapy; factor Xa inhibitors; pacemaker; artificial/adverse effects; plasma exchange; risk factors; stroke/prevention & control; treatment outcome; warfarin/therapeutic use; ORAL ANTICOAGULANTS; MANAGEMENT; INHIBITORS; PHARMACOKINETICS; COMPLICATIONS; THROMBIN; WARFARIN; SAFETY;

D O I：

10.14503/THIJ-14-4424

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report the case of an 82-year-old man in whom hemorrhagic pericardial effusion occurred one week after pacemaker implantation, while he was taking apixaban. Few therapies exist for reversing the anti-Xa effect of apixaban. To reverse anticoagulation, our patient underwent plasma exchange, which facilitated pericardiocentesis and prevented possible surgical intervention. To our knowledge, this is the first report of the use of plasmapheresis to reverse the anticoagulant effect of apixaban.

引用

页码：377 / 380

页数：4

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