Effects of Scutellaria baicalensis Extract on Cigarette Smoke-Induced Airway Inflammation in a Murine Model of Chronic Obstructive Pulmonary Disease

被引:14
作者
Yang, Won-Kyung [1 ,2 ]
Kim, Seung-Hyung [2 ]
Jung, In Chul [3 ]
Park, Yang-Chun [1 ,2 ]
机构
[1] Daejeon Univ, Coll Korean Med, Dept Internal Med, 62 Daehak Ro, Daejeon 34520, South Korea
[2] Daejeon Univ, Inst Tradit Med & Biosci, Daejeon, South Korea
[3] Daejeon Univ, Coll Korean Med, Dept Neuropsychiat, Daejeon, South Korea
关键词
airway inflammation; chronic obstructive pulmonary disease; cigarette smoke; Scutellaria baicalensis; OXIDATIVE STRESS; IN-VIVO; LIPOPOLYSACCHARIDE; BAICALIN; MICE; INHIBITION; EXPOSURE; WOGONIN; ASTHMA; CELLS;
D O I
10.1089/jmf.2018.4200
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Chronic obstructive pulmonary disease (COPD), including pulmonary emphysema and chronic bronchitis as well as structural and inflammatory changes in small airways, is insensitive to corticosteroid therapies. This study aimed to evaluate the effects of Scutellaria baicalensis root extract (SB_E) in a mouse model of COPD. The COPD mouse model was produced by challenging C57BL/6 mice with a cigarette smoke extract and lipopolysaccharide (LPS). SB_E significantly decreased the neutrophil counts in blood and bronchoalveolar lavage fluid (BALF), and the production of tumor necrosis factor (TNF)-alpha, interleukin (IL)-17A, macrophage inflammatory protein 2 (MIP2), and chemokine (C-X-C motif) ligand 1 (CXCL-1) in BALF, and TNF-alpha mRNA expression in lung tissue. The histological lung injury was also alleviated by treatment with SB_E. Thus, SB_E effectively inhibited airway inflammation by regulating the expression of inflammatory cytokines by blocking MIP2 and CXCL-1 secretion. Therefore, S. baicalensis may be a potential therapeutic agent for COPD.
引用
收藏
页码:87 / 96
页数:10
相关论文
共 50 条
[41]   Paclobutrazol ameliorates cigarette smoke-induced chronic obstructive pulmonary disease (COPD) in experimental rats [J].
Ma, Xuan ;
Zhang, Jinzhao ;
Wang, Shengyu ;
Li, Yaming ;
Ibrahim, Ibrahim Abdel Aziz ;
Diao, Xin .
ARABIAN JOURNAL OF CHEMISTRY, 2023, 16 (08)
[42]   Rutaecarpine Protects Against Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease (COPD) in Rats [J].
Ji, Zexuan ;
Zhang, Changhong ;
Feng, Ping ;
Zhao, Jianqing .
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2024, 196 (10) :7089-7103
[43]   Vitamin E isoform γ-tocotrienol alleviates cigarette smoke-induced chronic obstructive pulmonary disease [J].
Hong Yong PEH ;
Wan Shun Daniel TAN ;
Tze Khee CHAN ;
Chen Wei POW ;
Choon Nam ONG ;
WaiShiu Fred WONG .
中国药理学与毒理学杂志, 2015, 29(S1) (S1) :51-51
[44]   The role of HDAC2 in cigarette smoke-induced airway inflammation in a murine model of asthma and the effect of intervention with roxithromycin [J].
Xia, Mengling ;
Xu, Hui ;
Dai, Wei ;
Zhu, Cong ;
Wu, Liqin ;
Yan, Sunshun ;
Ge, Xiangting ;
Zhou, Wangfeng ;
Chen, Cuicui ;
Dai, Yuanrong .
JOURNAL OF ASTHMA, 2018, 55 (04) :337-344
[45]   Time course of cigarette smoke-induced pulmonary inflammation in mice [J].
D'hulst, AI ;
Vermaelen, KY ;
Brusselle, GG ;
Joos, GF ;
Pauwels, RA .
EUROPEAN RESPIRATORY JOURNAL, 2005, 26 (02) :204-213
[46]   Protective Effect of the Total Alkaloid Extract from Bulbus Fritillariae pallidiflorae in a Mouse Model of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease [J].
Wang, Xiaoyu ;
Aga, Er-Bu ;
Tse, Wai Ming ;
Tse, Kathy Wai Gaun ;
Ye, Bengui .
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2024, 19 :1273-1289
[47]   Everything Prevents Emphysema Are Animal Models of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease Any Use? [J].
Churg, Andrew ;
Sin, Don D. ;
Wright, Joanne L. .
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2011, 45 (06) :1111-1115
[48]   Critical role of aldehydes in cigarette smoke-induced acute airway inflammation [J].
Marco van der Toorn ;
Dirk-Jan Slebos ;
Harold G de Bruin ;
Renee Gras ;
Delaram Rezayat ;
Lucie Jorge ;
Koen Sandra ;
Antoon JM van Oosterhout .
Respiratory Research, 14
[49]   Cholesterol Accumulation Enhances Cigarette Smoke-Induced Airway Epithelial Inflammation [J].
Jing, Du ;
Yu, Jin-Kang ;
Chen, Hai-Pin ;
Dong, Ling-Ling ;
Li, Wen ;
Li, Zhou-Yang ;
Zhou, Jie-Sen .
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2025, 20 :411-423
[50]   The role of miR-155 in cigarette smoke-induced pulmonary inflammation and COPD [J].
De Smet, E. G. ;
Van Eeckhoutte, H. P. ;
Cobos, F. Avila ;
Blomme, E. ;
Verhamme, F. M. ;
Provoost, S. ;
Verleden, S. E. ;
Venken, K. ;
Maes, T. ;
Joos, G. F. ;
Mestdagh, P. ;
Brusselle, G. G. ;
Bracke, K. R. .
MUCOSAL IMMUNOLOGY, 2020, 13 (03) :423-436