Functions and transcriptional regulation of PAH-inducible human UDP-glucuronosyltransferases

被引:46
作者
Bock, KW [1 ]
Gschaidmeier, H [1 ]
Heel, H [1 ]
Lehmköster, T [1 ]
Münzel, PA [1 ]
Bock-Hennig, BS [1 ]
机构
[1] Univ Tubingen, Inst Toxicol, D-72074 Tubingen, Germany
关键词
UDP-glucuronyltransferase; human isoforms; induction by dioxins; benzo(a)pyrene metabolism;
D O I
10.1081/DMR-100101927
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:411 / 422
页数:12
相关论文
共 45 条
[11]  
EBNER T, 1993, MOL PHARMACOL, V43, P649
[12]  
EBNER T, 1993, DRUG METAB DISPOS, V21, P50
[13]   DRUG-RESPONSIVE AND TISSUE-SPECIFIC ALTERNATIVE EXPRESSION OF MULTIPLE FIRST EXONS IN RAT UDP-GLUCURONOSYLTRANSFERASE FAMILY-1 (UGTI) GENE-COMPLEX [J].
EMI, Y ;
IKUSHIRO, S ;
IYANAGI, T .
JOURNAL OF BIOCHEMISTRY, 1995, 117 (02) :392-399
[14]  
Emi Y, 1996, J BIOL CHEM, V271, P3952, DOI 10.1074/jbc.271.7.3952
[15]   EFFECTS OF PHENOBARBITAL AND 3-METHYLCHOLANTHRENE ON SUBSTRATE-SPECIFICITY OF RAT-LIVER MICROSOMAL UDP-GLUCURONYLTRANSFERASE [J].
FROHLING, KW ;
REMMER, H ;
REXER, B .
BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 327 (01) :46-56
[16]  
Green MD, 1996, DRUG METAB DISPOS, V24, P356
[17]  
GREEN MD, 1994, DRUG METAB DISPOS, V22, P799
[18]   Identification of a rat oltipraz-inducible UDP-glucuronosyltransferase (UGT1A7) with activity towards benzo(alpha)pyrene-7,8-dihydrodiol [J].
Grove, AD ;
Kessler, FK ;
Metz, RP ;
Ritter, JK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (03) :1621-1627
[19]   FORMATION OF MONOGLUCURONIDES AND DIGLUCURONIDES AND OTHER GLYCOSIDES OF BENZO(A)PYRENE-3,6-QUINOL BY V79 CELL-EXPRESSED HUMAN PHENOL UDP-GLUCURONOSYLTRANSFERASES OF THE UGT1 GENE-COMPLEX [J].
GSCHAIDMEIER, H ;
SEIDEL, A ;
BURCHELL, B ;
BOCK, KW .
BIOCHEMICAL PHARMACOLOGY, 1995, 49 (11) :1601-1606
[20]  
HILDEBRANDT AG, 1965, THESIS U TUBINGEN