Functions and transcriptional regulation of PAH-inducible human UDP-glucuronosyltransferases

被引：46

作者：

Bock, KW ^{[1
]}

Gschaidmeier, H ^{[1
]}

Heel, H ^{[1
]}

Lehmköster, T ^{[1
]}

Münzel, PA ^{[1
]}

Bock-Hennig, BS ^{[1
]}

机构：

[1] Univ Tubingen, Inst Toxicol, D-72074 Tubingen, Germany

来源：

DRUG METABOLISM REVIEWS | 1999年 / 31卷 / 02期

关键词：

UDP-glucuronyltransferase; human isoforms; induction by dioxins; benzo(a)pyrene metabolism;

D O I：

10.1081/DMR-100101927

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：411 / 422

页数：12

共 45 条

[1]

BECKER M, 1990, CURRENT RES PHOTOSYN, V1, P101

[2] QUINOL DIGLUCURONIDES ARE PREDOMINANT CONJUGATED METABOLITES FOUND IN BILE OF RATS FOLLOWING INTRATRACHEAL INSTILLATION OF BENZO[A]PYRENE [J].

BEVAN, DR ;

SADLER, VM .

CARCINOGENESIS, 1992, 13 (03) :403-407

[3] PARACETAMOL GLUCURONIDATION BY RECOMBINANT RAT AND HUMAN PHENOL UDP-GLUCURONOSYLTRANSFERASES [J].

BOCK, KW ;

FORSTER, A ;

GSCHAIDMEIER, H ;

BRUCK, M ;

MUNZEL, P ;

SCHARECK, W ;

FOURNELGIGLEUX, S ;

BURCHELL, B .

BIOCHEMICAL PHARMACOLOGY, 1993, 45 (09) :1809-1814

[4] THE INFLUENCE OF ENVIRONMENTAL AND GENETIC-FACTORS ON CYP2D6, CYP1A2 AND UDP-GLUCURONOSYLTRANSFERASES IN MAN USING SPARTEINE, CAFFEINE, AND PARACETAMOL AS PROBES [J].

BOCK, KW ;

SCHRENK, D ;

FORSTER, A ;

GRIESE, EU ;

MORIKE, K ;

BROCKMEIER, D ;

EICHELBAUM, M .

PHARMACOGENETICS, 1994, 4 (04) :209-218

[5] PARACETAMOL AS A TEST DRUG TO DETERMINE GLUCURONIDE FORMATION IN MAN - EFFECTS OF INDUCERS AND OF SMOKING [J].

BOCK, KW ;

WILTFANG, J ;

BLUME, R ;

ULLRICH, D ;

BIRCHER, J .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1987, 31 (06) :677-683

[6] Regulation of the human bilirubin UDP-glucuronosyltransferase gene [J].

Brierley, CH ;

Senafi, SB ;

Clarke, D ;

Hsu, MH ;

Johnson, EF ;

Burchell, B .

ADVANCES IN ENZYME REGULATION, VOL 36, 1996, 36 :85-97

[7] FUNCTION AND REGULATION OF UDP-GLUCURONOSYLTRANSFERASE GENES IN HEALTH AND LIVER-DISEASE - REPORT OF THE 7TH INTERNATIONAL WORKSHOP ON GLUCURONIDATION, SEPTEMBER-1993, PITLOCHRY, SCOTLAND [J].

BURCHELL, B ;

COUGHTRIE, MWH ;

JANSEN, PLM .

HEPATOLOGY, 1994, 20 (06) :1622-1630

[8]

Coffman BL, 1997, DRUG METAB DISPOS, V25, P1

[9]

CONNEY AH, 1982, CANCER RES, V42, P4875

[10]

DUTTON GJ, 1980, GLUCURONIDATION DRUG, P23

← 1 2 3 4 5 →